Activated Leukocyte Cell Adhesion Molecule (ALCAM) Antibody – Rabbit Polyclonal

This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

ALCAM: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.11

Cellular Component: axon; cell soma; dendrite; external side of plasma membrane; focal adhesion; immunological synapse; integral component of plasma membrane; intrinsic component of plasma membrane; T cell receptor complex

Molecular Function: protein binding; receptor binding

Biological Process: adaptive immune response; axon extension involved in axon guidance; cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; motor axon guidance; retinal ganglion cell axon guidance; signal transduction