Selectin, Leukocyte (SELL) Antibody – Rabbit Polyclonal

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: external side of plasma membrane; integral component of plasma membrane; plasma membrane; secretory granule membrane

Molecular Function: carbohydrate binding; cell adhesion molecule binding; glycosphingolipid binding; heparin binding; protease binding; protein binding

Biological Process: cell adhesion; leukocyte migration; neutrophil degranulation; regulation of immune response; response to ATP

Disease: Iga Nephropathy, Susceptibility To, 1