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Interleukin 1 Receptor Antagonist (IL1RA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002916
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MBS2002916 is an antibody targeting IL1RA. Also known as Polyclonal Antibody to Interleukin 1 Receptor Antagonist (IL1RA). Reactive in Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin 1 Receptor Antagonist (IL1RA), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Interleukin 1 Receptor Antagonist (IL1RA)
Product Gene Name
anti-IL1RA antibody
Immunogen Sequence
Antigen: The target protein is fused with a His-tag and its sequence is listed below.
MGHHHHHHSG SEF-RPSG KRPCKMQAFR IWDTNQKTFY LRNNQLIAGY LQGPNIKLEE KIDMVPIDLH SVFLGIHGGK LCLSCAKSGD DIKLQLEEVN ITDLSKNKEE DKRFTFIRSE KGPTTSFESA ACPGWFLCTT LEADRPVSLT NTPEEPLIVT KFYFQEDQ
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against IL1RA. It has been selected for its ability to recognize IL1RA in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: IL1RA (MBS2002916)
Biotin Conjugated Antibody: IL1RA (MBS2004361)
Matching Pairs
Unconjugated Antibody: IL1RA (MBS2002916)
Immunogen: IL1RA (MBS2011716)
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Molecular Weight
17,996 Da
3D Structure
ModBase 3D Structure for P25085
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant IL1RA (Arg27~Gln178) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2039789
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-IL1RA antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-IL1RA antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-IL1RA antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-IL1RA Polyclonal Antibody – Cat# MBS2002916

Immunohistochemistry (IHC) of anti-IL1RA antibody

DAB staining on fromalin fixed paraffin-embedded Liver tissue)
Rabbit Anti-IL1RA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002916

Other Notes

Small volumes of anti-IL1RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL1RA. It may not necessarily be applicable to this product.

NCBI GI #
89257344
NCBI GeneID
16181
NCBI Accession #
NP_001034790.1
UniProt Primary Accession #
P25085
UniProt Secondary Accession #
O70207
UniProt Related Accession #
P25085
GenBank Nucleotide #
NM_001039701.3
NCBI Official Full Name
interleukin-1 receptor antagonist protein isoform 2
NCBI Official Synonym Full Names
interleukin 1 receptor antagonist
NCBI Official Symbol
Il1rn
NCBI Official Synonym Symbols
IL-1ra; F630041P17Rik
UniProt Protein Name
Interleukin-1 receptor antagonist protein
UniProt Synonym Protein Names
IL1 inhibitor
UniProt Gene Name
Il1rn
UniProt Synonym Gene Names
Il-1ra; IL-1RN; IL-1ra; IRAP
NCBI Protein Information
interleukin-1 receptor antagonist protein

UniProt Comments for IL1RA

IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide; Vesicle

Chromosomal Location of Human Ortholog: 2 A3|2 16.36 cM

Cellular Component: cytoplasm; extracellular region; extracellular space; vesicle

Molecular Function: cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type I receptor binding; interleukin-1, Type II receptor binding

Biological Process: acute-phase response; cytokine-mediated signaling pathway; fever; immune response; inflammatory response; insulin secretion; lipid metabolic process; memory; negative regulation of apoptosis; negative regulation of cell migration; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; negative regulation of membrane potential; positive regulation of JUN kinase activity; response to glucocorticoid stimulus; sensory perception of pain
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Research Articles on IL1RA

1. Following vasectomy, IL1alpha, IL1beta, IL1ra, IL10, and TNF-alpha may mediate immune reaction in whole epididymis, whereas IL6 and TGF-beta1 may mediate regionally different immune response primarily in the lower part of epididymis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL1RA antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram

Diseases associated with anti-IL1RA antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >778 publications with IL1RA and Necrosis
 Inflammation Antibodies  >697 publications with IL1RA and Inflammation
 Arthritis, Rheumatoid Antibodies  >302 publications with IL1RA and Arthritis, Rheumatoid
 Cardiovascular Diseases Antibodies  >190 publications with IL1RA and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >165 publications with IL1RA and Disease Models, Animal
 Skin Diseases Antibodies  >126 publications with IL1RA and Skin Diseases
 Lung Diseases Antibodies  >111 publications with IL1RA and Lung Diseases
 Pain Antibodies  >82 publications with IL1RA and Pain
 Kidney Diseases Antibodies  >80 publications with IL1RA and Kidney Diseases
 Heart Diseases Antibodies  >76 publications with IL1RA and Heart Diseases

Organs/Tissues associated with anti-IL1RA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1072 publications with IL1RA and Blood
 Skin Antibodies  >127 publications with IL1RA and Skin
 Bone Marrow Antibodies  >67 publications with IL1RA and Bone Marrow
 Stomach Antibodies  >51 publications with IL1RA and Stomach
 Connective Tissue Antibodies  >50 publications with IL1RA and Connective Tissue
 Spleen Antibodies  >43 publications with IL1RA and Spleen
 Intestine Antibodies  >40 publications with IL1RA and Intestine
 Eye Antibodies  >38 publications with IL1RA and Eye
 Vagina Antibodies  >11 publications with IL1RA and Vagina
 Thymus Antibodies  >7 publications with IL1RA and Thymus
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