Spleen Tyrosine Kinase (SYK) Antibody – Rabbit Polyclonal

Syk: a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Syk family; TK group

Chromosomal Location of Human Ortholog: 13 A5|13 27.41 cM

Cellular Component: B cell receptor complex; cytoplasm; cytoplasmic vesicle; extrinsic component of cytoplasmic side of plasma membrane; membrane; nucleus; plasma membrane; protein complex; T cell receptor complex

Molecular Function: ATP binding; integrin binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatase binding; phosphotyrosine binding; protein binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; SH2 domain binding; signal transducer, downstream of receptor, with protein tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding

Biological Process: activation of JNK activity; activation of MAPK activity; adaptive immune response; angiogenesis; B cell receptor signaling pathway; beta selection; blood vessel morphogenesis; cell migration; cell surface receptor signaling pathway; cellular response to low-density lipoprotein particle stimulus; collagen-activated tyrosine kinase receptor signaling pathway; defense response to bacterium; enzyme linked receptor protein signaling pathway; G-protein coupled receptor signaling pathway; immune system process; innate immune response; integrin-mediated signaling pathway; leukocyte activation involved in immune response; leukocyte adhesion; leukotriene biosynthetic process; lymph vessel development; macrophage activation involved in immune response; neutrophil activation during immune response; neutrophil chemotaxis; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of bone resorption; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of cytokine secretion; positive regulation of gamma-delta T cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interferon type I production; positive regulation of interleukin-3 biosynthetic process; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; protein amino acid phosphorylation; protein autophosphorylation; receptor internalization; regulation of arachidonic acid secretion; regulation of ERK1 and ERK2 cascade; regulation of immune response; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of platelet activation; regulation of platelet aggregation; regulation of superoxide release; regulation of transcription factor activity; regulation of tumor necrosis factor-mediated signaling pathway; serotonin secretion; serotonin secretion by platelet; transcription factor import into nucleus