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Glycogen Phosphorylase, Liver (PYGL) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002951
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MBS2002951 is an antibody targeting PYGL. Also known as Polyclonal Antibody to Glycogen Phosphorylase, Liver (PYGL). Reactive in Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glycogen Phosphorylase, Liver (PYGL), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Glycogen Phosphorylase, Liver (PYGL)
Product Gene Name
anti-PYGL antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- TVIIGGKA APGYHMAKMI IKLVTSVAEV VNNDPMVGSK LKVIFLENYR VSLAEKVIPA TDLSEQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM AEEAGEENLF IFGMRVDDVA ALDKKGYEAK EYYEALPELK LVIDQIDNGF
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against PYGL. It has been selected for its ability to recognize PYGL in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: PYGL (MBS2002951)
Immunogen: PYGL (MBS2009442)
Matching Pairs
Unconjugated Antibody: PYGL (MBS2002951)
APC-CY7 Conjugated Antibody: PYGL (MBS2048625)
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Molecular Weight
97,483 Da
3D Structure
ModBase 3D Structure for P09811
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant PYGL (Thr603~Phe750) expressed in E.coli.
Cross Reactivity
Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2048633
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-PYGL antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-PYGL antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-PYGL antibody

Western Blot: Sample: Mouse Cerebrum lysate; Primary Ab: 2ug/mL Rabbit Anti-Rat PYGL Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-PYGL Polyclonal Antibody – Cat# MBS2002951

Western Blot (WB) of anti-PYGL antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-PYGL Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002951

Immunohistochemistry (IHC) of anti-PYGL antibody

DAB staining on IHC-P. Samples: Rat Tissue)
Rabbit Anti-PYGL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002951

Other Notes

Small volumes of anti-PYGL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PYGL. It may not necessarily be applicable to this product.

NCBI GI #
11560087
NCBI GeneID
64035
NCBI Accession #
NP_071604.1
UniProt Primary Accession #
P09811
UniProt Related Accession #
P09811
GenBank Nucleotide #
NM_022268.1
NCBI Official Full Name
glycogen phosphorylase, liver form
NCBI Official Synonym Full Names
glycogen phosphorylase L
NCBI Official Symbol
Pygl
UniProt Protein Name
Glycogen phosphorylase, liver form
Protein Family
Glycogen phosphorylase
UniProt Gene Name
Pygl
UniProt Synonym Gene Names
Lgp
NCBI Protein Information
glycogen phosphorylase, liver form

NCBI Summary for PYGL

catalyzes the rate-limiting step of glycogen catabolism [RGD, Feb 2006]

UniProt Comments for PYGL

PYGL: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Defects in PYGL are the cause of glycogen storage disease type 6 (GSD6). A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected. Belongs to the glycogen phosphorylase family.

Protein type: Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Transferase

Chromosomal Location of Human Ortholog: 6q24

Cellular Component: cytoplasm

Molecular Function: AMP binding; ATP binding; bile acid binding; carbohydrate binding; drug binding; glycogen phosphorylase activity; protein homodimerization activity; purine binding; pyridoxal phosphate binding; vitamin binding

Biological Process: 5-phosphoribose 1-diphosphate biosynthetic process; glucose homeostasis; glycogen catabolic process; glycogen metabolic process
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Research Articles on PYGL

1. Data show that two biomarkers, glycine N-methyltransferase (GNMT) and glycogen phosphorylase (PYGL), were found to indicate early hepatic injuries.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PYGL antibody

 Reference Product  PubMed Publications
 Phkb antibody  >3 publications with PYGL and Phkb
 Gys1 antibody  >3 publications with PYGL and Gys1
 Gys2 antibody  >1 publications with PYGL and Gys2
 Pgm1 antibody  >1 publications with PYGL and Pgm1
 Agl antibody  >1 publications with PYGL and Agl

Pathways associated with anti-PYGL antibody

 Products by Pathway  Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycogen Metabolism Pathway antibodies  Glycogen Metabolism Pathway Diagram
 Glycogen Breakdown (glycogenolysis) Pathway antibodies  Glycogen Breakdown (glycogenolysis) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Insulin Resistance Pathway antibodies  Insulin Resistance Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram

Diseases associated with anti-PYGL antibody

 Disease Name  Pubmed Publications
 Glycogen Storage Disease Type VI Antibodies  >6 publications with PYGL and Glycogen Storage Disease Type VI
 Hepatomegaly Antibodies  >5 publications with PYGL and Hepatomegaly
 Liver Diseases Antibodies  >5 publications with PYGL and Liver Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with PYGL and Drug-Related Side Effects and Adverse Reactions
 Weight Gain Antibodies  >1 publications with PYGL and Weight Gain
 Hypertrophy Antibodies  >1 publications with PYGL and Hypertrophy
 Fibrosis Antibodies  >1 publications with PYGL and Fibrosis
 Fatty Liver Antibodies  >1 publications with PYGL and Fatty Liver
 Drug-Induced Liver Injury Antibodies  >1 publications with PYGL and Drug-Induced Liver Injury
 Poisoning Antibodies  >1 publications with PYGL and Poisoning

Organs/Tissues associated with anti-PYGL antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >15 publications with PYGL and Liver
 Heart Antibodies  >2 publications with PYGL and Heart
 Ovary Antibodies  >1 publications with PYGL and Ovary
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