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Glutathione Synthetase (GSS) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002963
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MBS2002963 is an antibody targeting GSS. Also known as Polyclonal Antibody to Glutathione Synthetase (GSS). Reactive in Human, Rat. Host: Rabbit. More details

$220 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glutathione Synthetase (GSS), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Glutathione Synthetase (GSS)
Product Gene Name
anti-GSS antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-Y MPSQYNAQNW EARLLLERSC AAKCPDIATQ LAGTKKVQQE LSRVGLLEAL LPGQPEAVAR LRATFAGLYS LDMGEEGDQA VAEALAAPSH FVLKPQREGG GNNFYGEEMV HALEQLKDSE ERASYILMEK IEPEPFRNCL LRPGSPAQVV QCISELGIFG VYVRQGTTLV MNKHVGHLLR TKAIEHADGG VAAGVAVLDN PYPV
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against GSS. It has been selected for its ability to recognize GSS in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: GSS (MBS2002963)
Immunogen: GSS (MBS2009236)
Matching Pairs
Unconjugated Antibody: GSS (MBS2002963)
APC-CY7 Conjugated Antibody: GSS (MBS2072757)
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Molecular Weight
52,345 Da
3D Structure
ModBase 3D Structure for P46413
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant GSS (Tyr270~Val474) expressed in E.coli.
Cross Reactivity
Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2072759
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-GSS antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-GSS antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-GSS antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-GSS Polyclonal Antibody – Cat# MBS2002963

Immunohistochemistry (IHC) of anti-GSS antibody

DAB staining on IHC-P; Samples: Rat Kidney Tissue)
Rabbit Anti-GSS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002963

Other Notes

Small volumes of anti-GSS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GSS. It may not necessarily be applicable to this product.

NCBI GI #
25742757
NCBI GeneID
25458
NCBI Accession #
NP_037094.1
UniProt Primary Accession #
P46413
UniProt Related Accession #
P46413
GenBank Nucleotide #
NM_012962.1
NCBI Official Full Name
glutathione synthetase
NCBI Official Synonym Full Names
glutathione synthetase
NCBI Official Symbol
Gss
UniProt Protein Name
Glutathione synthetase
UniProt Synonym Protein Names
Glutathione synthase
Protein Family
Bifunctional glutathionylspermidine synthetase/amidase
UniProt Gene Name
Gss
UniProt Synonym Gene Names
GSH synthetase; GSH-S
NCBI Protein Information
glutathione synthetase

NCBI Summary for GSS

catalyzes the synthesis of glutathione from gamma-L-glutamyl-L-cysteine and glycine; activity is ATP-dependent [RGD, Feb 2006]

UniProt Comments for GSS

GSS: Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency); also known as 5- oxoprolinuria or pyroglutamic aciduria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes (GLUSYNDE)[MIM:231900]. Glutathione synthetase deficiency of erythrocytes is a mild form causing hemolytic anemia. Belongs to the eukaryotic GSH synthase family.

Protein type: EC 6.3.2.3; Ligase; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 3q42

Cellular Component: cytosol

Molecular Function: ATP binding; glutathione binding; glutathione synthase activity; glycine binding; identical protein binding; magnesium ion binding; peptide binding; protein homodimerization activity

Biological Process: aging; amino acid metabolic process; glutathione biosynthetic process; response to amino acid; response to cadmium ion; response to nutrient levels; response to xenobiotic stimulus
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Research Articles on GSS

1. role of AP-1 in induction by tert-butylhydroquinone

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GSS antibody

 Reference Product  PubMed Publications
 Gclc antibody  >20 publications with GSS and Gclc
 Gsr antibody  >12 publications with GSS and Gsr
 Gclm antibody  >8 publications with GSS and Gclm
 Gstp1 antibody  >2 publications with GSS and Gstp1

Pathways associated with anti-GSS antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Glutathione Biosynthesis, Glutamate => Glutathione Pathway antibodies  Glutathione Biosynthesis, Glutamate => Glutathione Pathway Diagram
 Glutathione Biosynthesis, Glutamate => Glutathione Pathway antibodies  Glutathione Biosynthesis, Glutamate => Glutathione Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Synthesis And Recycling Pathway antibodies  Glutathione Synthesis And Recycling Pathway Diagram

Diseases associated with anti-GSS antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >115 publications with GSS and Immune System Diseases
 Death Antibodies  >45 publications with GSS and Death
 Disease Models, Animal Antibodies  >33 publications with GSS and Disease Models, Animal
 Inflammation Antibodies  >29 publications with GSS and Inflammation
 Atrophy Antibodies  >26 publications with GSS and Atrophy
 Carcinoma Antibodies  >22 publications with GSS and Carcinoma
 Chromosome Aberrations Antibodies  >18 publications with GSS and Chromosome Aberrations
 Heart Diseases Antibodies  >16 publications with GSS and Heart Diseases
 Cognition Disorders Antibodies  >14 publications with GSS and Cognition Disorders
 Memory Disorders Antibodies  >14 publications with GSS and Memory Disorders

Organs/Tissues associated with anti-GSS antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >35 publications with GSS and Liver
 Eye Antibodies  >32 publications with GSS and Eye
 Prostate Antibodies  >27 publications with GSS and Prostate
 Heart Antibodies  >25 publications with GSS and Heart
 Kidney Antibodies  >21 publications with GSS and Kidney
 Ovary Antibodies  >17 publications with GSS and Ovary
 Spleen Antibodies  >8 publications with GSS and Spleen
 Colon Antibodies  >8 publications with GSS and Colon
 Dorsal Root Ganglion Antibodies  >5 publications with GSS and Dorsal Root Ganglion
 Connective Tissue Antibodies  >5 publications with GSS and Connective Tissue
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