Caveolin 1 (CAV1) Antibody – Rabbit Polyclonal

caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 6|6 A2

Cellular Component: acrosomal membrane; apical plasma membrane; basal plasma membrane; basolateral plasma membrane; caveola; cell cortex; cell surface; cilium; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endosome; focal adhesion; Golgi apparatus; Golgi membrane; integral component of membrane; integral component of plasma membrane; intracellular; lipid droplet; membrane; membrane raft; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; plasma membrane; protein complex

Molecular Function: ATPase binding; enzyme binding; identical protein binding; inward rectifier potassium channel inhibitor activity; ion channel binding; kinase binding; nitric-oxide synthase binding; protease activator activity; protein binding; protein binding, bridging; protein complex scaffold activity; protein heterodimerization activity; protein kinase binding; Rac GTPase binding; receptor binding; SNARE binding; structural molecule activity; syntaxin binding

Biological Process: angiogenesis; angiotensin-activated signaling pathway involved in heart process; calcium ion homeostasis; calcium ion transport; caveolin-mediated endocytosis; cellular calcium ion homeostasis; cellular response to exogenous dsRNA; cellular response to hyperoxia; cellular response to peptide hormone stimulus; cellular response to transforming growth factor beta stimulus; cellular senescence; cholesterol efflux; cholesterol homeostasis; endocytosis; inactivation of MAPK activity; lactation; lipid storage; maintenance of cellular protein localization; mammary gland development; mammary gland involution; membrane depolarization; microtubule polymerization; negative regulation of anoikis; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cation channel activity; negative regulation of cell proliferation; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of ERK1 and ERK2 cascade; negative regulation of JAK-STAT cascade; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of muscle cell apoptotic process; negative regulation of neuron differentiation; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine autophosphorylation; negative regulation of pinocytosis; negative regulation of potassium ion transmembrane transport; negative regulation of protein binding; negative regulation of protein ubiquitination; negative regulation of signal transduction; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; nitric oxide homeostasis; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt signaling pathway; positive regulation of catalytic activity; positive regulation of endocytosis; positive regulation of endothelial cell proliferation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of signal transduction; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; posttranscriptional regulation of gene expression; protein homooligomerization; protein localization; protein oligomerization; receptor internalization; receptor internalization involved in canonical Wnt signaling pathway; receptor-mediated endocytosis of virus by host cell; regulation of blood coagulation; regulation of cytosolic calcium ion concentration; regulation of entry of bacterium into host cell; regulation of fatty acid metabolic process; regulation of heart rate by cardiac conduction; regulation of membrane repolarization during action potential; regulation of peptidase activity; regulation of ruffle assembly; regulation of smooth muscle contraction; regulation of the force of heart contraction; regulation of the force of heart contraction by chemical signal; regulation of ventricular cardiac muscle cell action potential; response to bacterium; response to calcium ion; response to estrogen; response to hypoxia; response to mechanical stimulus; response to progesterone; skeletal muscle tissue development; T cell costimulation; triacylglycerol metabolic process; vasculogenesis; vasoconstriction; wound healing