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Interleukin 1 Receptor Antagonist (IL1RA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2003023
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MBS2003023 is an antibody targeting IL1RA. Also known as Polyclonal Antibody to Interleukin 1 Receptor Antagonist (IL1RA). Reactive in Human, Pig. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin 1 Receptor Antagonist (IL1RA), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Interleukin 1 Receptor Antagonist (IL1RA)
Product Gene Name
anti-IL1RA antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Pig
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.35mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: IL1RA (MBS2003023)
Biotin Conjugated Antibody: IL1RA (MBS2005210)
Matching Pairs
Unconjugated Antibody: IL1RA (MBS2003023)
Immunogen: IL1RA (MBS2011238)
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OMIM
X53296 mRNA
3D Structure
ModBase 3D Structure for P18510
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Cross Reactivity
Porcine
Immunogen
Recombinant IL1RA (Arg26~Glu177) expressed in E.coli (MBS2011238)
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-IL1RA antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP)
Application Notes for anti-IL1RA antibody
Western blotting: 0.5-3ug/mL
Immunohistochemistry: 5-30ug/mL
Immunocytochemistry: 5-30ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-IL1RA antibody

Western Blot:
Sample: Recombinant IL1RA, Human.
Rabbit Anti-IL1RA Polyclonal Antibody – Cat# MBS2003023

Western Blot (WB) of anti-IL1RA antibody

Western Blot;
Sample:
Lane 1: A431 cell lysate;
Lane 2: Human Saliva
Primary Ab: 3ug/ml Rabbit Anti-Human IL1RA Antibody
Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-IL1RA Polyclonal Antibody, Western Blot (WB) – Cat# MBS2003023

Immunohistochemistry (IHC) of anti-IL1RA antibody

DAB staining on IHC-P;
Samples: Human Stomach Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Human IL1RA Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-IL1RA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003023

Other Notes

Small volumes of anti-IL1RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL1RA. It may not necessarily be applicable to this product.

NCBI GI #
10835147
NCBI GeneID
3557
NCBI Accession #
NP_000568.1
UniProt Primary Accession #
P18510
UniProt Secondary Accession #
Q14628; Q53SC2; Q7RTZ4; Q96GD6; Q9UPC0; A8K4G1
UniProt Related Accession #
P18510
GenBank Nucleotide #
NM_000577.4
NCBI Official Full Name
interleukin-1 receptor antagonist protein isoform 3
NCBI Official Synonym Full Names
interleukin 1 receptor antagonist
NCBI Official Symbol
IL1RN
NCBI Official Synonym Symbols
DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
UniProt Protein Name
Interleukin-1 receptor antagonist protein
UniProt Synonym Protein Names
ICIL-1RA; IL1 inhibitor; INN: Anakinra
UniProt Gene Name
IL1RN
UniProt Synonym Gene Names
IL1F3; IL1RA; IL-1RN; IL-1ra; IRAP
NCBI Protein Information
interleukin-1 receptor antagonist protein

NCBI Summary for IL1RA

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
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UniProt Comments for IL1RA

IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide; Vesicle

Chromosomal Location of Human Ortholog: 2q14.1

Cellular Component: cytoplasm; extracellular space; intracellular; plasma membrane

Molecular Function: cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type I receptor binding; interleukin-1, Type II receptor binding; protein binding

Biological Process: fever; immune response; insulin secretion; lipid metabolic process; negative regulation of heterotypic cell-cell adhesion; response to glucocorticoid stimulus

Disease: Gastric Cancer, Hereditary Diffuse; Microvascular Complications Of Diabetes, Susceptibility To, 4; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis
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Research Articles on IL1RA

1. Reconstitution of ST2 (IL-1R4) specific for IL-33 activity; no suppression by IL-1Ra though a common chain IL-1R3 (IL-1RAcP) shared with IL-1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL1RA antibody

 Reference Product  PubMed Publications
 IL1A antibody  >78 publications with IL1RA and IL1A
 IL4 antibody  >21 publications with IL1RA and IL4
 IL8 antibody  >20 publications with IL1RA and IL8
 IL1R1 antibody  >16 publications with IL1RA and IL1R1
 MMP3 antibody  >5 publications with IL1RA and MMP3
 IL1R2 antibody  >5 publications with IL1RA and IL1R2
 IL1RL2 antibody  >2 publications with IL1RA and IL1RL2
 SELE antibody  >1 publications with IL1RA and SELE

Pathways associated with anti-IL1RA antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram

Diseases associated with anti-IL1RA antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >758 publications with IL1RA and Necrosis
 Inflammation Antibodies  >665 publications with IL1RA and Inflammation
 Arthritis, Rheumatoid Antibodies  >306 publications with IL1RA and Arthritis, Rheumatoid
 Cardiovascular Diseases Antibodies  >183 publications with IL1RA and Cardiovascular Diseases
 Skin Diseases Antibodies  >119 publications with IL1RA and Skin Diseases
 Lung Diseases Antibodies  >105 publications with IL1RA and Lung Diseases
 Pain Antibodies  >79 publications with IL1RA and Pain
 Kidney Diseases Antibodies  >77 publications with IL1RA and Kidney Diseases
 Heart Diseases Antibodies  >74 publications with IL1RA and Heart Diseases
 Liver Diseases Antibodies  >56 publications with IL1RA and Liver Diseases

Organs/Tissues associated with anti-IL1RA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1042 publications with IL1RA and Blood
 Brain Antibodies  >168 publications with IL1RA and Brain
 Skin Antibodies  >123 publications with IL1RA and Skin
 Lung Antibodies  >106 publications with IL1RA and Lung
 Liver Antibodies  >105 publications with IL1RA and Liver
 Heart Antibodies  >75 publications with IL1RA and Heart
 Stomach Antibodies  >44 publications with IL1RA and Stomach
 Spleen Antibodies  >43 publications with IL1RA and Spleen
 Eye Antibodies  >38 publications with IL1RA and Eye
 Intestine Antibodies  >37 publications with IL1RA and Intestine
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