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Fascin 2 (FSCN2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2003032
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2003032 is an antibody targeting FSCN2. Also known as Polyclonal Antibody to Fascin 2 (FSCN2). Reactive in Human. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fascin 2 (FSCN2), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Fascin 2 (FSCN2)
Product Gene Name
anti-FSCN2 antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- QVLKIQF GLVNDTDRYL TAESFGFKVN ASAPSLKRKQ TWVLEPDPGQ GTAVLLRSSH LGRYLSAEED GRVACEAEQP GRDCRFLVLP QPDGRWVLRS EPHGRFFGGT EDQLSCFATA VSPAELWTVH LAIHPQAHLL SVSRRRYVHL CPREDEMAAD GDKPWGVDAL LTLIFRSRRY CLKSCDSRYL RSDGRLVWEP EPRACYTLEF KAGKLAFKDC DGHYLAPVGP AGTLKAGRNT RPGKDELFDL EESH
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against FSCN2. It has been selected for its ability to recognize FSCN2 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: FSCN2 (MBS2003032)
Biotin Conjugated Antibody: FSCN2 (MBS2002208)
Matching Pairs
Unconjugated Antibody: FSCN2 (MBS2003032)
Immunogen: FSCN2 (MBS2009515)
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Molecular Weight
57,381 Da
OMIM
AF030165 mRNA
3D Structure
ModBase 3D Structure for O14926
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant FSCN2 (Gln8~His258) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2074967
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-FSCN2 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-FSCN2 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-FSCN2 antibody

Western Blot: Sample: Human Placenta lysate; Primary Ab: 1ug/ml Rabbit Anti-Human FSCN2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-FSCN2 Polyclonal Antibody – Cat# MBS2003032

Western Blot (WB) of anti-FSCN2 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-FSCN2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2003032

Immunohistochemistry (IHC) of anti-FSCN2 antibody

DAB staining on IHC-P. Samples: Human Tissue)
Rabbit Anti-FSCN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003032

Other Notes

Small volumes of anti-FSCN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FSCN2. It may not necessarily be applicable to this product.

NCBI GI #
116295251
NCBI GeneID
25794
NCBI Accession #
NP_001070650.1
UniProt Primary Accession #
O14926
UniProt Secondary Accession #
A0AVC4; A8MRA6
UniProt Related Accession #
O14926
GenBank Nucleotide #
NM_001077182.2
NCBI Official Full Name
fascin-2 isoform 2
NCBI Official Synonym Full Names
fascin actin-bundling protein 2, retinal
NCBI Official Symbol
FSCN2
NCBI Official Synonym Symbols
RFSN; RP30
UniProt Protein Name
Fascin-2
UniProt Synonym Protein Names
Retinal fascin
Protein Family
Fascin
UniProt Gene Name
FSCN2
NCBI Protein Information
fascin-2

NCBI Summary for FSCN2

This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FSCN2

FSCN2: Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Defects in FSCN2 are the cause of retinitis pigmentosa type 30 (RP30). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP30 inheritance is autosomal dominant. Belongs to the fascin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: actin cytoskeleton; cytoplasm; filamentous actin; stereocilium

Molecular Function: actin binding; actin filament binding; protein binding, bridging

Biological Process: actin cytoskeleton organization; actin filament bundle formation; anatomical structure morphogenesis; cell migration; establishment and/or maintenance of cell polarity; eye photoreceptor cell development; visual perception

Disease: Retinitis Pigmentosa 30
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Research Articles on FSCN2

1. diffuse expression in 82% of undifferentiated/dedifferentiated endometrial carcinomas

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FSCN2 antibody

 Disease Name  Pubmed Publications
 Nerve Degeneration Antibodies  >1 publications with FSCN2 and Nerve Degeneration
 Atrophy Antibodies  >1 publications with FSCN2 and Atrophy

Organs/Tissues associated with anti-FSCN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >12 publications with FSCN2 and Eye
 Brain Antibodies  >2 publications with FSCN2 and Brain
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