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Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2003118
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MBS2003118 is an antibody targeting HBEGF. Also known as Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF). Reactive in Human, Pig. Host: Rabbit. More details

$195 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF)
Product Gene Name
anti-HBEGF antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-VTGESL ERLR RGLAAGTSNP DPPTVSTDQL LPLGGGRDRK VRDLQEADLD LLRVTLSSKP QALATPNKEE HGKRKKKGKG LGKKRDPCLR KYKDFCIHGE CKYVKELRAP SCICHPGYHG ERCHGLSLPV ENRLYTYDHT
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Pig
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against HBEGF. It has been selected for its ability to recognize HBEGF in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: HBEGF (MBS2003118)
Biotin Conjugated Antibody: HBEGF (MBS2002948)
Matching Pairs
Unconjugated Antibody: HBEGF (MBS2003118)
Immunogen: HBEGF (MBS2010267)
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Molecular Weight
23,067 Da
OMIM
M60278 mRNA
3D Structure
ModBase 3D Structure for Q99075
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant HBEGF (Val21~Thr160) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2055653
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-HBEGF antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-HBEGF antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-HBEGF antibody

Western Blot: Sample: Recombinant HBEGF, Human.
Rabbit Anti-HBEGF Polyclonal Antibody – Cat# MBS2003118

Immunohistochemistry (IHC) of anti-HBEGF antibody

DAB staining on fromalin fixed paraffin-embedded Heart tissue)
Rabbit Anti-HBEGF Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003118

Other Notes

Small volumes of anti-HBEGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HBEGF. It may not necessarily be applicable to this product.

NCBI GI #
4503413
NCBI GeneID
1839
NCBI Accession #
NP_001936.1
UniProt Primary Accession #
Q99075
UniProt Secondary Accession #
B2R821
UniProt Related Accession #
Q99075
GenBank Nucleotide #
NM_001945.2
NCBI Official Full Name
proheparin-binding EGF-like growth factor
NCBI Official Synonym Full Names
heparin binding EGF like growth factor
NCBI Official Symbol
HBEGF
NCBI Official Synonym Symbols
DTR; DTS; DTSF; HEGFL
UniProt Protein Name
Proheparin-binding EGF-like growth factor
UniProt Synonym Protein Names
Heparin-binding EGF-like growth factor; HB-EGF; HBEGF
Protein Family
Proheparin-binding EGF-like growth factor
UniProt Gene Name
HBEGF
UniProt Synonym Gene Names
DTR; DTS; HEGFL; HB-EGF; HBEGF; DT-R
NCBI Protein Information
proheparin-binding EGF-like growth factor

UniProt Comments for HBEGF

HBEGF: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: cell surface; extracellular region; extracellular space; integral component of plasma membrane; plasma membrane

Molecular Function: epidermal growth factor receptor binding; growth factor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; MAPK cascade; muscle organ development; negative regulation of elastin biosynthetic process; negative regulation of ERBB signaling pathway; peptidyl-tyrosine phosphorylation; phosphatidylinositol phosphorylation; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of keratinocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell proliferation; positive regulation of wound healing; regulation of cell motility; regulation of heart contraction; regulation of receptor activity; signal transduction; wound healing, spreading of epidermal cells
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Research Articles on HBEGF

1. HB-EGF is implicated in DNA double strand breaks repair as silencing of HB-EGF increased gammaH2AX foci half-life as well as USP9X expression, two features that could be linked to the observed effect on Mcl-1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HBEGF antibody

 Reference Product  PubMed Publications
 EGFR antibody  >19 publications with HBEGF and EGFR
 IL8 antibody  >4 publications with HBEGF and IL8
 MMP7 antibody  >2 publications with HBEGF and MMP7
 MMP9 antibody  >1 publications with HBEGF and MMP9
 NRG2 antibody  >1 publications with HBEGF and NRG2
 CD9 antibody  >1 publications with HBEGF and CD9
 ADAM17 antibody  >1 publications with HBEGF and ADAM17
 ERBB2 antibody  >1 publications with HBEGF and ERBB2
 ERBB4 antibody  >1 publications with HBEGF and ERBB4

Pathways associated with anti-HBEGF antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 EGFR Transactivation By Gastrin Pathway antibodies  EGFR Transactivation By Gastrin Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram

Diseases associated with anti-HBEGF antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with HBEGF and Neoplasms
 Cardiovascular Diseases Antibodies  >10 publications with HBEGF and Cardiovascular Diseases
 Inflammation Antibodies  >7 publications with HBEGF and Inflammation
 Necrosis Antibodies  >7 publications with HBEGF and Necrosis
 Heart Diseases Antibodies  >5 publications with HBEGF and Heart Diseases
 Disease Models, Animal Antibodies  >5 publications with HBEGF and Disease Models, Animal
 Lung Diseases Antibodies  >4 publications with HBEGF and Lung Diseases
 Hypertrophy Antibodies  >3 publications with HBEGF and Hypertrophy
 Neoplasms, Experimental Antibodies  >3 publications with HBEGF and Neoplasms, Experimental
 Fibrosis Antibodies  >2 publications with HBEGF and Fibrosis

Organs/Tissues associated with anti-HBEGF antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with HBEGF and Blood
 Placenta Antibodies  >10 publications with HBEGF and Placenta
 Muscle Antibodies  >10 publications with HBEGF and Muscle
 Lung Antibodies  >10 publications with HBEGF and Lung
 Vascular Antibodies  >9 publications with HBEGF and Vascular
 Uterus Antibodies  >6 publications with HBEGF and Uterus
 Skin Antibodies  >6 publications with HBEGF and Skin
 Bone Antibodies  >6 publications with HBEGF and Bone
 Liver Antibodies  >6 publications with HBEGF and Liver
 Embryonic Tissue Antibodies  >6 publications with HBEGF and Embryonic Tissue
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