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Jagged 1 Protein (JAG1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2003138
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MBS2003138 is an antibody targeting JAG1. Also known as Polyclonal Antibody to Jagged 1 Protein (JAG1). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Jagged 1 Protein (JAG1), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Jagged 1 Protein (JAG1)
Product Gene Name
anti-JAG1 antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-G YRCICPPGYA GDHCERDIDE CASNPCLNGG HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK CPEDYEGKNC SHLKDHCRTT PCEVIDSCTV AMASNDTPEG VRYISSNVCG PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCRN GGTCIDGVNS YKCICSDGWE GAYCETNIND CSQNPCHNGG TCRDLVNDFY CDCKNGWKGK TCHSRDSQCD EATCNNGGTC YDEGDAFKCM CPGGWEGTTC NIARNSSCLP NPCHNGGTCV VNGESFTCVC KEGWEGPICA QNTNDCSPHP CYNSGTCVDG DNWYRCECAP GFAGPDCRIN INECQSSPCA FGAT
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against JAG1. It has been selected for its ability to recognize JAG1 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: JAG1 (MBS2003138)
Immunogen: JAG1 (MBS2011360)
Matching Pairs
Unconjugated Antibody: JAG1 (MBS2003138)
APC-CY7 Conjugated Antibody: JAG1 (MBS2059325)
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Molecular Weight
116,579 Da
OMIM
AF003837 mRNA
3D Structure
ModBase 3D Structure for P78504
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant JAG1 (Gly470~Thr834) expressed in E.coli.
Cross Reactivity
Human, Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2059331
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-JAG1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-JAG1 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-JAG1 antibody

Western Blot: Sample: Rat Uterus Tissue.
Rabbit Anti-JAG1 Polyclonal Antibody – Cat# MBS2003138

Western Blot (WB) of anti-JAG1 antibody

Western Blot: Sample: Recombinant JAG1, Human.
Rabbit Anti-JAG1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2003138

Immunohistochemistry (IHC) of anti-JAG1 antibody

DAB staining on IHC-P. Samples: Human Tissue)
Rabbit Anti-JAG1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003138

Other Notes

Small volumes of anti-JAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.

NCBI GI #
4557679
NCBI GeneID
182
NCBI Accession #
NP_000205.1
UniProt Primary Accession #
P78504
UniProt Secondary Accession #
O14902; O15122; Q15816; A0AV43; B4DYR1; E9PCF9
UniProt Related Accession #
P78504
GenBank Nucleotide #
NM_000214.2
NCBI Official Full Name
protein jagged-1
NCBI Official Synonym Full Names
jagged 1
NCBI Official Symbol
JAG1
NCBI Official Synonym Symbols
AGS; AHD; AWS; HJ1; AGS1; CD339; JAGL1
UniProt Protein Name
Protein jagged-1
UniProt Synonym Protein Names
CD_antigen: CD339
Protein Family
Protein jagged
UniProt Gene Name
JAG1
UniProt Synonym Gene Names
JAGL1; Jagged1; hJ1
NCBI Protein Information
protein jagged-1

NCBI Summary for JAG1

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for JAG1

JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p12.2

Cellular Component: adherens junction; apical plasma membrane; extracellular region; integral component of plasma membrane; membrane; plasma membrane

Molecular Function: calcium ion binding; growth factor activity; Notch binding; phospholipid binding; protein binding; structural molecule activity

Biological Process: angiogenesis; auditory receptor cell differentiation; blood vessel remodeling; cell fate determination; endothelial cell differentiation; hemopoiesis; keratinocyte differentiation; morphogenesis of an epithelial sheet; myoblast differentiation; negative regulation of endothelial cell differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; nervous system development; Notch receptor processing; Notch signaling pathway; positive regulation of myeloid cell differentiation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of cell proliferation; response to muramyl dipeptide; T cell mediated immunity

Disease: Alagille Syndrome 1; Tetralogy Of Fallot
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Research Articles on JAG1

1. Jagged1 (JAG1) thymic medullary niche enriched for dendritic cells (DC)-lineage cells expressing Notch receptors indicate thymus as a DC-poietic organ, which provides selective microenvironments permissive for DC development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JAG1 antibody

 Reference Product  PubMed Publications
 NOTCH1 antibody  >85 publications with JAG1 and NOTCH1
 NOTCH2 antibody  >58 publications with JAG1 and NOTCH2
 DLL1 antibody  >34 publications with JAG1 and DLL1
 NOTCH3 antibody  >34 publications with JAG1 and NOTCH3
 HES5 antibody  >19 publications with JAG1 and HES5
 ADAM10 antibody  >2 publications with JAG1 and ADAM10
 MIB1 antibody  >2 publications with JAG1 and MIB1
 UBC antibody  >1 publications with JAG1 and UBC

Pathways associated with anti-JAG1 antibody

 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram

Diseases associated with anti-JAG1 antibody

 Disease Name  Pubmed Publications
 Alagille Syndrome Antibodies  >125 publications with JAG1 and Alagille Syndrome
 Liver Diseases Antibodies  >108 publications with JAG1 and Liver Diseases
 Heart Defects, Congenital Antibodies  >108 publications with JAG1 and Heart Defects, Congenital
 Facies Antibodies  >31 publications with JAG1 and Facies
 Heart Diseases Antibodies  >29 publications with JAG1 and Heart Diseases
 Carcinoma Antibodies  >28 publications with JAG1 and Carcinoma
 Breast Neoplasms Antibodies  >23 publications with JAG1 and Breast Neoplasms
 Tetralogy of Fallot Antibodies  >17 publications with JAG1 and Tetralogy of Fallot
 Bone Diseases Antibodies  >15 publications with JAG1 and Bone Diseases
 Eye Abnormalities Antibodies  >15 publications with JAG1 and Eye Abnormalities

Organs/Tissues associated with anti-JAG1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with JAG1 and Blood
 Brain Antibodies  >30 publications with JAG1 and Brain
 Embryonic Tissue Antibodies  >29 publications with JAG1 and Embryonic Tissue
 Kidney Antibodies  >19 publications with JAG1 and Kidney
 Lung Antibodies  >10 publications with JAG1 and Lung
 Placenta Antibodies  >8 publications with JAG1 and Placenta
 Pancreas Antibodies  >8 publications with JAG1 and Pancreas
 Connective Tissue Antibodies  >7 publications with JAG1 and Connective Tissue
 Uterus Antibodies  >5 publications with JAG1 and Uterus
 Intestine Antibodies  >5 publications with JAG1 and Intestine
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