Mothers Against Decapentaplegic Homolog 3 (SMAD3) Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]

SMAD3: transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton.

Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 15q22.33

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nuclear inner membrane; nucleoplasm; nucleus; plasma membrane; receptor complex; SMAD protein complex; SMAD2-SMAD3 protein complex; transcription factor complex

Molecular Function: beta-catenin binding; bHLH transcription factor binding; chromatin DNA binding; co-SMAD binding; collagen binding; DEAD/H-box RNA helicase binding; DNA binding transcription factor activity; glucocorticoid receptor binding; identical protein binding; mineralocorticoid receptor binding; phosphatase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; R-SMAD binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding

Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; activin receptor signaling pathway; cell cycle arrest; cell-cell junction organization; cellular response to transforming growth factor beta stimulus; developmental growth; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endoderm development; evasion or tolerance of host defenses by virus; heart looping; immune response; immune system development; in utero embryonic development; lens fiber cell differentiation; liver development; mesoderm formation; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of fat cell differentiation; negative regulation of inflammatory response; negative regulation of lung blood pressure; negative regulation of mitotic cell cycle; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; nodal signaling pathway; osteoblast development; paraxial mesoderm morphogenesis; pericardium development; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of chondrocyte differentiation; positive regulation of epithelial to mesenchymal transition; positive regulation of extracellular matrix assembly; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of nitric oxide biosynthetic process; positive regulation of positive chemotaxis; positive regulation of stress fiber formation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta3 production; primary microRNA processing; protein deubiquitination; protein stabilization; reduction of cytosolic calcium ion concentration; regulation of binding; regulation of epithelial cell proliferation; regulation of immune response; regulation of striated muscle tissue development; regulation of transcription from RNA polymerase II promoter; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor-beta2 production; response to hypoxia; SMAD protein complex assembly; somitogenesis; T cell activation; thyroid gland development; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud development; Wnt receptor signaling pathway through beta-catenin; wound healing

Disease: Loeys-dietz Syndrome 3