Nitric Oxide Synthase 3, Endothelial (NOS3) Antibody – Rabbit Polyclonal

eNOS: endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.

Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase

Chromosomal Location of Human Ortholog: 4q11

Cellular Component: apical part of cell; caveola; cytoplasm; cytoskeleton; cytosol; Golgi apparatus; membrane raft; mitochondrion; nucleolus; nucleus; plasma membrane; sarcolemma; vesicle membrane

Molecular Function: actin binding; actin monomer binding; arginine binding; beta-catenin binding; cadherin binding; calmodulin binding; FAD binding; FMN binding; heme binding; Hsp90 protein binding; iron ion binding; NADP binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; nitric-oxide synthase binding; protein binding; tetrahydrobiopterin binding

Biological Process: aging; angiogenesis; arginine catabolic process; blood vessel remodeling; cellular response to cAMP; cellular response to growth factor stimulus; cellular response to heat; cellular response to magnesium ion; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; endothelial cell migration; female pregnancy; in utero embryonic development; lipopolysaccharide-mediated signaling pathway; lung development; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of cell proliferation; negative regulation of hydrolase activity; negative regulation of muscle hyperplasia; negative regulation of potassium ion transport; negative regulation of smooth muscle cell proliferation; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; ovulation from ovarian follicle; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of blood vessel diameter; positive regulation of guanylate cyclase activity; regulation of blood vessel size; regulation of sodium ion transport; regulation of systemic arterial blood pressure by endothelin; regulation of the force of heart contraction by chemical signal; removal of superoxide radicals; response to activity; response to amino acid; response to axon injury; response to candesartan; response to corticosterone stimulus; response to cytokine; response to drug; response to estradiol; response to ethanol; response to fructose stimulus; response to high density lipoprotein stimulus; response to hyperoxia; response to hypoxia; response to ketone; response to lead ion; response to lipopolysaccharide; response to mechanical stimulus; response to metal ion; response to organic cyclic compound; response to peptide; response to peptide hormone; response to salt; retina development in camera-type eye; signal transduction; smooth muscle hyperplasia