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Quiescin Q6 Sulfhydryl Oxidase 1 (QSOX1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2003269
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MBS2003269 is an antibody targeting QSOX1. Also known as Polyclonal Antibody to Quiescin Q6 Sulfhydryl Oxidase 1 (QSOX1). Reactive in Human, Mouse. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Quiescin Q6 Sulfhydryl Oxidase 1 (QSOX1), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Quiescin Q6 Sulfhydryl Oxidase 1 (QSOX1)
Product Gene Name
anti-QSOX1 antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-SPSD PLTLLQADTV RGAVLGSRSA WAVEFFASWC GHCIAFAPTW KALAEDVKAW RPALYLAALD CAEETNSAVC RDFNIPGFPT VRFFKAFTKN GSGAVFPVAG ADVQTLRERL IDALESHHDT WPPACPPLEP AKLEEIDGFF A
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against QSOX1. It has been selected for its ability to recognize QSOX1 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: QSOX1 (MBS2003269)
Immunogen: QSOX1 (MBS2011601)
Matching Pairs
Unconjugated Antibody: QSOX1 (MBS2003269)
APC-CY7 Conjugated Antibody: QSOX1 (MBS2068033)
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Molecular Weight
66,861 Da
OMIM
U97276 mRNA
3D Structure
ModBase 3D Structure for O00391
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant QSOX1 (Ser37~Ala181) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2068037
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-QSOX1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-QSOX1 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-QSOX1 antibody

Western Blot: Sample: Human Lung lysate; Primary Ab: 1ug/ml Rabbit Anti-Human QSOX1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-QSOX1 Polyclonal Antibody – Cat# MBS2003269

Western Blot (WB) of anti-QSOX1 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-QSOX1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2003269

Immunohistochemistry (IHC) of anti-QSOX1 antibody

DAB staining on fromalin fixed paraffin- embedded liver tissue)
Rabbit Anti-QSOX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003269

Immunohistochemistry (IHC) of anti-QSOX1 antibody

DAB staining on IHC-P; Samples: Human Liver Tissue)
Rabbit Anti-QSOX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003269

Other Notes

Small volumes of anti-QSOX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for QSOX1. It may not necessarily be applicable to this product.

NCBI GI #
51873067
NCBI GeneID
5768
NCBI Accession #
NP_001004128.1
UniProt Primary Accession #
O00391
UniProt Secondary Accession #
Q59G29; Q5T2X0; Q8TDL6; Q8WVP4
UniProt Related Accession #
O00391
GenBank Nucleotide #
NM_001004128.2
NCBI Official Full Name
sulfhydryl oxidase 1 isoform b
NCBI Official Synonym Full Names
quiescin sulfhydryl oxidase 1
NCBI Official Symbol
QSOX1
NCBI Official Synonym Symbols
Q6; QSCN6
UniProt Protein Name
Sulfhydryl oxidase 1
UniProt Synonym Protein Names
Quiescin Q6
Protein Family
Sulfhydryl oxidase
UniProt Gene Name
QSOX1
UniProt Synonym Gene Names
QSCN6; hQSOX
NCBI Protein Information
sulfhydryl oxidase 1

NCBI Summary for QSOX1

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for QSOX1

quiescin Q6: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.8.3.2; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; integral to Golgi membrane; intercellular bridge; intracellular membrane-bound organelle; tertiary granule lumen

Molecular Function: flavin-linked sulfhydryl oxidase activity; protein disulfide isomerase activity

Biological Process: cell redox homeostasis; cellular protein metabolic process; negative regulation of macroautophagy; neutrophil degranulation; platelet degranulation; post-translational protein modification
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Research Articles on QSOX1

1. Data indicate ebselen as an in vitro inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1) enzymatic activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-QSOX1 antibody

 Reference Product  PubMed Publications
 GFER antibody  >2 publications with QSOX1 and GFER

Diseases associated with anti-QSOX1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >6 publications with QSOX1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >3 publications with QSOX1 and Breast Neoplasms
 Heart Diseases Antibodies  >2 publications with QSOX1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >2 publications with QSOX1 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >1 publications with QSOX1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >1 publications with QSOX1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with QSOX1 and Lung Neoplasms
 Nervous System Diseases Antibodies  >1 publications with QSOX1 and Nervous System Diseases
 Atherosclerosis Antibodies  >1 publications with QSOX1 and Atherosclerosis
 Inflammation Antibodies  >1 publications with QSOX1 and Inflammation

Organs/Tissues associated with anti-QSOX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with QSOX1 and Blood
 Liver Antibodies  >5 publications with QSOX1 and Liver
 Prostate Antibodies  >4 publications with QSOX1 and Prostate
 Heart Antibodies  >4 publications with QSOX1 and Heart
 Lung Antibodies  >4 publications with QSOX1 and Lung
 Pancreas Antibodies  >2 publications with QSOX1 and Pancreas
 Vascular Antibodies  >2 publications with QSOX1 and Vascular
 Muscle Antibodies  >2 publications with QSOX1 and Muscle
 Bone Antibodies  >2 publications with QSOX1 and Bone
 Lymph Node Antibodies  >1 publications with QSOX1 and Lymph Node
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