Rabbit Anti-TNNI1 Polyclonal Antibody – Cat# MBS2003322

Troponin I Type 1, Slow Skeletal (TNNI1) Antibody – Rabbit Polyclonal

Name: TNNI1 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS2003322
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2003322

MBS2003322 is an antibody targeting TNNI1. Also known as Biotin-Linked Antibody to Troponin I Type 1, Slow Skeletal (TNNI1). Reactive in Rat, Human, Mouse, Pig. Host: Rabbit. More details

$235 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Troponin I Type 1, Slow Skeletal (TNNI1), Polyclonal Antibody

Full Product Name

Biotin-Linked Antibody to Troponin I Type 1, Slow Skeletal (TNNI1)

Product Gene Name

anti-TNNI1 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Rat, Human, Mouse, Pig

Form/Format

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

Purity/Purification

Affinity Chromatography

Concentration

500ug/ml (lot specific)

Specificity

The antibody is a rabbit polyclonal antibody raised against TNNI1 conjugated to biotin. It has been selected for its ability to recognize TNNI1 in immunohistochemical staining andwestern blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Matching Pairs

Unconjugated Antibody: TNNI1 (MBS2002481)
Biotin Conjugated Antibody: TNNI1 (MBS2003322)

Matching Pairs

Biotin Conjugated Antibody: TNNI1 (MBS2003322)
Immunogen: TNNI1 (MBS2011997)

Molecular Weight

21,692 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (201372895..201390874, complement). Location: 1q31.3

OMIM

191042

3D Structure

ModBase 3D Structure for P19237

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Product Categories/Family for anti-TNNI1 antibody

Biotin Antibody

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-TNNI1 antibody

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

Application Notes for anti-TNNI1 antibody

Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Other Notes

Small volumes of anti-TNNI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNNI1. It may not necessarily be applicable to this product.

NCBI GI #

15214933

NCBI GeneID

7135

NCBI Accession #

AAH12601.1

UniProt Primary Accession #

P19237

UniProt Secondary Accession #

Q659A5; Q6FGS7; Q6FGW1; Q6ICU2; Q86T57; Q96DT9; A6NEH3; A8MSJ0

UniProt Related Accession #

P19237

NCBI Official Full Name

Troponin I type 1 (skeletal, slow)

NCBI Official Synonym Full Names

troponin I type 1 (skeletal, slow)

NCBI Official Symbol

TNNI1

NCBI Official Synonym Symbols

TNN1; SSTNI

UniProt Protein Name

Troponin I, slow skeletal muscle

UniProt Synonym Protein Names

Troponin I, slow-twitch isoform

Protein Family

Troponin

UniProt Gene Name

TNNI1

UniProt Entry Name

TNNI1_HUMAN

NCBI Protein Information

troponin I, slow skeletal muscle; troponin I, slow-twitch isoform

NCBI Summary for TNNI1

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]

UniProt Comments for TNNI1

TNNI1: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin I family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 1q31.3

Cellular Component: troponin complex; cytosol

Molecular Function: metal ion binding; actin binding

Biological Process: regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; muscle filament sliding

Research Articles on TNNI1

1. sTnI as a sensitive marker of skeletal muscle injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TNNI1 antibody

Products by Pathway	Pathway Diagram
Muscle Contraction Pathway antibodies	Muscle Contraction Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram

Diseases associated with anti-TNNI1 antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>1 publications with TNNI1 and Heart Diseases
Cardiovascular Diseases Antibodies	>1 publications with TNNI1 and Cardiovascular Diseases
Necrosis Antibodies	>1 publications with TNNI1 and Necrosis
Hypertrophy Antibodies	>1 publications with TNNI1 and Hypertrophy

Organs/Tissues associated with anti-TNNI1 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>15 publications with TNNI1 and Muscle
Heart Antibodies	>7 publications with TNNI1 and Heart
Brain Antibodies	>1 publications with TNNI1 and Brain
Spinal Cord Antibodies	>1 publications with TNNI1 and Spinal Cord
Embryonic Tissue Antibodies	>1 publications with TNNI1 and Embryonic Tissue
Lung Antibodies	>1 publications with TNNI1 and Lung