Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody – Rabbit Polyclonal

nNOS: nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex. Four alternatively spliced isoforms have been described.

Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase

Chromosomal Location of Human Ortholog: 5 F|5 57.29 cM

Cellular Component: azurophil granule; caveola; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; membrane; membrane raft; mitochondrial outer membrane; mitochondrion; nuclear membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; postsynaptic density; protein complex; sarcolemma; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; synapse; T-tubule; vesicle membrane; Z disc

Molecular Function: ATPase binding; cadmium ion binding; calmodulin binding; enzyme binding; FAD binding; FMN binding; heme binding; ion channel binding; iron ion binding; metal ion binding; NADP binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; oxidoreductase activity; phosphoprotein binding; protein binding; protein homodimerization activity; sodium channel regulator activity

Biological Process: arginine catabolic process; behavioral response to cocaine; cellular response to epinephrine stimulus; cellular response to growth factor stimulus; establishment of protein localization; exogenous drug catabolic process; multicellular organismal response to stress; negative regulation of apoptosis; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of cell proliferation; negative regulation of heart contraction; negative regulation of hydrolase activity; negative regulation of insulin secretion; negative regulation of peptidyl-serine phosphorylation; negative regulation of potassium ion transport; negative regulation of serotonin uptake; negative regulation of vasoconstriction; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of adrenergic receptor signaling pathway involved in heart process; positive regulation of blood vessel diameter; positive regulation of guanylate cyclase activity; positive regulation of histone acetylation; positive regulation of long-term synaptic potentiation; positive regulation of neuron death; positive regulation of sodium ion transmembrane transport; positive regulation of the force of heart contraction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; reduction of cytosolic calcium ion concentration; regulation of heart contraction; regulation of neurogenesis; regulation of sensory perception of pain; regulation of sodium ion transport; response to estrogen; response to heat; response to peptide hormone; retrograde trans-synaptic signaling by nitric oxide; striated muscle contraction; vasodilation