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Macrophage Inflammatory Protein 4 Alpha (MIP4a) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2003365
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MBS2003365 is an antibody targeting MIP4a. Also known as Polyclonal Antibody to Macrophage Inflammatory Protein 4 Alpha (MIP4a). Reactive in Human. Host: Rabbit. More details

$190 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Macrophage Inflammatory Protein 4 Alpha (MIP4a), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Macrophage Inflammatory Protein 4 Alpha (MIP4a)
Product Gene Name
anti-MIP4a antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS - TRGSDIS KTCCFQYSHK PLPWTWVRSY EFTSNSCSQR AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against MIP4a. It has been selected for its ability to recognize MIP4a in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: MIP4a (MBS2003365)
Biotin Conjugated Antibody: MIP4a (MBS2002254)
Matching Pairs
Unconjugated Antibody: MIP4a (MBS2003365)
Immunogen: MIP4a (MBS2010625)
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Molecular Weight
10,648 Da
OMIM
AF124601 mRNA
3D Structure
ModBase 3D Structure for Q9Y258
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant MIP4a (Thr24~Leu94) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2062973
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-MIP4a antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-MIP4a antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-MIP4a antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-MIP4a Polyclonal Antibody – Cat# MBS2003365

Immunohistochemistry (IHC) of anti-MIP4a antibody

DAB staining on fromalin fixed paraffin-embedded Heart tissue)
Rabbit Anti-MIP4a Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003365

Other Notes

Small volumes of anti-MIP4a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP4a. It may not necessarily be applicable to this product.

NCBI GI #
5174671
NCBI GeneID
10344
NCBI Accession #
NP_006063.1
UniProt Primary Accession #
Q9Y258
UniProt Secondary Accession #
Q52LV8; A0N0Q5
UniProt Related Accession #
Q9Y258
GenBank Nucleotide #
NM_006072.4
NCBI Official Full Name
C-C motif chemokine 26
NCBI Official Synonym Full Names
C-C motif chemokine ligand 26
NCBI Official Symbol
CCL26
NCBI Official Synonym Symbols
IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
UniProt Protein Name
C-C motif chemokine 26
UniProt Synonym Protein Names
CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1
UniProt Gene Name
CCL26
UniProt Synonym Gene Names
SCYA26; MIP-4-alpha; TSC-1
NCBI Protein Information
C-C motif chemokine 26

NCBI Summary for MIP4a

This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
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UniProt Comments for MIP4a

CCL26: Chemotactic for eosinophils and basophils. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: extracellular space

Molecular Function: CCR3 chemokine receptor binding; chemokine activity; receptor ligand activity

Biological Process: cell-cell signaling; chemotaxis; G-protein coupled receptor signaling pathway; inflammatory response; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of chemotaxis; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; response to organonitrogen compound; signal transduction
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Research Articles on MIP4a

1. Based on the ADEPT study data set, we report that airway mucosal expression of CCL26 was a robust discriminator of type 2 inflammation from healthy nonatopic subjects. Furthermore, airway mucosal CCL26 expression was best identified by using a panel of clinical biomarkers, including Feno values, bEOS counts, and expression of 2 novel markers, sCCL17 and sCCL26
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MIP4a antibody

 Reference Product  PubMed Publications
 CCR3 antibody  >67 publications with MIP4a and CCR3
 STAT6 antibody  >26 publications with MIP4a and STAT6
 CCR2 antibody  >11 publications with MIP4a and CCR2
 CCR5 antibody  >9 publications with MIP4a and CCR5
 CCR1 antibody  >8 publications with MIP4a and CCR1
 CXCR3 antibody  >4 publications with MIP4a and CXCR3
 CCR8 antibody  >4 publications with MIP4a and CCR8
 CX3CR1 antibody  >4 publications with MIP4a and CX3CR1
 CCR6 antibody  >3 publications with MIP4a and CCR6

Pathways associated with anti-MIP4a antibody

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram

Diseases associated with anti-MIP4a antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >83 publications with MIP4a and Inflammation
 Lung Diseases Antibodies  >45 publications with MIP4a and Lung Diseases
 Eosinophilic Esophagitis Antibodies  >22 publications with MIP4a and Eosinophilic Esophagitis
 Necrosis Antibodies  >20 publications with MIP4a and Necrosis
 Cardiovascular Diseases Antibodies  >12 publications with MIP4a and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >6 publications with MIP4a and Congenital Abnormalities
 Fibrosis Antibodies  >4 publications with MIP4a and Fibrosis
 Heart Diseases Antibodies  >4 publications with MIP4a and Heart Diseases
 Hyperplasia Antibodies  >4 publications with MIP4a and Hyperplasia
 Arthritis, Rheumatoid Antibodies  >3 publications with MIP4a and Arthritis, Rheumatoid

Organs/Tissues associated with anti-MIP4a antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >43 publications with MIP4a and Lung
 Eye Antibodies  >8 publications with MIP4a and Eye
 Liver Antibodies  >7 publications with MIP4a and Liver
 Muscle Antibodies  >6 publications with MIP4a and Muscle
 Brain Antibodies  >5 publications with MIP4a and Brain
 Intestine Antibodies  >5 publications with MIP4a and Intestine
 Kidney Antibodies  >3 publications with MIP4a and Kidney
 Heart Antibodies  >3 publications with MIP4a and Heart
 Connective Tissue Antibodies  >2 publications with MIP4a and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with MIP4a and Uncharacterized Tissue
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