Fatty Acid Transport Protein 5 (FATP5) Antibody – Rabbit Polyclonal

SLC27A5: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Membrane protein, multi-pass; EC 6.2.1.7; Membrane protein, integral; Lipid Metabolism - primary bile acid biosynthesis; Endoplasmic reticulum; Ligase

Cellular Component: protein complex; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; integral to membrane; basal plasma membrane; integral to endoplasmic reticulum membrane

Molecular Function: cholate-CoA ligase activity; fatty acid transporter activity; protein complex binding; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; catalytic activity; ATP binding; long-chain-fatty-acid-CoA ligase activity; ligase activity

Biological Process: bile acid biosynthetic process; very-long-chain fatty acid metabolic process; metabolic process; bile acid metabolic process; ketone body biosynthetic process; lipid metabolic process; long-chain fatty acid metabolic process; triacylglycerol mobilization; fatty acid metabolic process; plasma membrane long-chain fatty acid transport; fatty acid transport