Calnexin (CNX) ELISA Kit for Human

Name: Human CNX ELISA Kit; Calnexin; MyBioSource
Brand: MyBioSource
SKU: MBS020036
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS020036

Background: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used to determine the level of CNX (hereafter termed "analyte") in undiluted original… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Calnexin (CNX), ELISA Kit

Full Product Name

Human Calnexin ELISA Kit

Product Gene Name

CNX elisa kit

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Detection Range

0.625ng/ml-20ng/ml

Sensitivity

0.1ng/ml

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Intra-assay Precision

Intra-assay CV (%) is less than 15%.

Molecular Weight

67,568 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (179125930..179158642). Location: 5q35

OMIM

114217

3D Structure

ModBase 3D Structure for P27824

Other Notes

Small volumes of CNX elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNX purchase

MBS020036 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Calnexin (CNX) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CNX. The ELISA analytical biochemical technique of the MBS020036 kit is based on CNX antibody-CNX antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CNX antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CNX. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CNX. It may not necessarily be applicable to this product.

NCBI GI #

66933005

NCBI GeneID

821

NCBI Accession #

NP_001019820.1

UniProt Primary Accession #

P27824

UniProt Secondary Accession #

B2R5V8; D3DWQ3

UniProt Related Accession #

P27824

GenBank Nucleotide #

NM_001024649.1

NCBI Official Full Name

calnexin

NCBI Official Synonym Full Names

calnexin

NCBI Official Symbol

CANX

NCBI Official Synonym Symbols

CNX; P90; IP90

UniProt Protein Name

Calnexin

UniProt Synonym Protein Names

IP90; Major histocompatibility complex class I antigen-binding protein p88; p90

Protein Family

Calnexin

UniProt Gene Name

CANX

UniProt Entry Name

CALX_HUMAN

NCBI Protein Information

calnexin; major histocompatibility complex class I antigen-binding protein p88

NCBI Summary for CNX

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

UniProt Comments for CNX

Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum .Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Calcium-binding; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; rough endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum; dendritic spine; cell soma; membrane; axon; melanosome; ribosome

Molecular Function: ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; carbohydrate binding; glycoprotein binding

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging

Research Articles on CNX

1. These findings demonstrated that calnexin strictly monitors the maturation of S protein by its direct binding, resulting in conferring infectivity on severe acute respiratory syndrome coronavirus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CNX elisa kit

Reference Product	PubMed Publications
CALR elisa kit	>2 publications with CNX and CALR
PDIA3 elisa kit	>1 publications with CNX and PDIA3

Pathways associated with CNX elisa kit

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies	Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
Assembly Of Viral Components At The Budding Site Pathway antibodies	Assembly Of Viral Components At The Budding Site Pathway Diagram
Calnexin/calreticulin Cycle Pathway antibodies	Calnexin/calreticulin Cycle Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram

Diseases associated with CNX elisa kit

Disease Name	Pubmed Publications
Carcinoma Antibodies	>2 publications with CNX and Carcinoma
Adenocarcinoma Antibodies	>2 publications with CNX and Adenocarcinoma
Neoplasms Antibodies	>2 publications with CNX and Neoplasms
Gastrointestinal Diseases Antibodies	>1 publications with CNX and Gastrointestinal Diseases
Liver Diseases Antibodies	>1 publications with CNX and Liver Diseases

Organs/Tissues associated with CNX elisa kit

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>2 publications with CNX and Lung
Liver Antibodies	>2 publications with CNX and Liver
Testis Antibodies	>2 publications with CNX and Testis
Epididymis Antibodies	>1 publications with CNX and Epididymis
Blood Antibodies	>1 publications with CNX and Blood
Kidney Antibodies	>1 publications with CNX and Kidney
Skin Antibodies	>1 publications with CNX and Skin
Uterus Antibodies	>1 publications with CNX and Uterus
Embryonic Tissue Antibodies	>1 publications with CNX and Embryonic Tissue