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MYC Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200394

A myc tag is a polypeptide protein tag derived from the c-myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild type… More details

$285 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Myc tag, Monoclonal Antibody
Full Product Name
Myc tag antibody
Product Gene Name
anti-MYC antibody
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
AT19B4
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Purity/Purification
By protein-A affinity chromatography
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
50,565 Da
3D Structure
ModBase 3D Structure for P01106
Antigen Species
Human
Immunogen
Recombinant human C-Myc (410-419aa) with tag purified from E. coli
Clone Note
Anti-human Myc tag mAb, clone AT19B4, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SNCA-Myc tag protein.

Product Categories/Family for anti-MYC antibody

Fusion Tag & Detection
Applications Tested/Suitable for anti-MYC antibody
ELISA (EIA), Western Blot (WB)

Western Blot (WB) of anti-MYC antibody

The recombinant human SNCA-Myc tag protein (50ng) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Myc tag antibody. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1. : Anti-human Myc tag monoclonal antibody (1:1000) Lane 2. : Anti-Human Myc tag monoclonal antibody (1:5000) Lane 3. : Anti-Human Myc tag monoclonal antibody (1:10000) The recombinant protein were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Myc tag antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1. : Recombinant Human SNCA-Myc tag (20ng) Lane 2. : Recombinant Human Myc-GST tag (50ng) Lane 3. : Recombinant Human s100A8-Myc tag (50ng) Lane 4. : Recombinant Human CHI3L1-Myc tag (50ng)
Mouse Anti-MYC Monoclonal Antibody – Cat# MBS200394

Product References and Citations for anti-MYC antibody

Cotterman R., et al. (2008) Cancer Res. 68 (23): 9654-9662.; Finver SN., et al. (1988) P NATL ACAD SCI. USA 85 (9): 3052-3056.

Other Notes

Small volumes of anti-MYC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYC purchase

MBS200394 is an antibody targeting MYC. Also known as Myc tag antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MYC. It may not necessarily be applicable to this product.

NCBI GI #
71774083
NCBI GeneID
4609
NCBI Accession #
NP_002458
UniProt Primary Accession #
P01106
UniProt Secondary Accession #
P01107; Q14026; A8WFE7
UniProt Related Accession #
P01106
GenBank Nucleotide #
NM_002467.5
NCBI Official Full Name
myc proto-oncogene protein isoform 1
NCBI Official Synonym Full Names
MYC proto-oncogene, bHLH transcription factor
NCBI Official Symbol
MYC
NCBI Official Synonym Symbols
MRTL; MYCC; c-Myc; bHLHe39
UniProt Protein Name
Myc proto-oncogene protein
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Protein Family
Myc protein
UniProt Gene Name
MYC
UniProt Synonym Gene Names
BHLHE39; bHLHe39
NCBI Protein Information
myc proto-oncogene protein

NCBI Summary for MYC

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
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UniProt Comments for MYC

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).

Research Articles on MYC

1. Further analysis indicated that JQ1 inhibited the recruitment of BDR4 to the promoter complex of the Myc and Ccnd1 genes in rat thyroid follicular PCCL3 cells, resulting in decreased MYC expression at the mRNA and protein levels to inhibit tumor cell proliferation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYC antibody

 Reference Product  PubMed Publications
 JUN antibody  >4210 publications with MYC and JUN
 MYB antibody  >813 publications with MYC and MYB
 BCL2 antibody  >792 publications with MYC and BCL2
 TP53 antibody  >668 publications with MYC and TP53
 CDKN1A antibody  >642 publications with MYC and CDKN1A
 CDKN2A antibody  >464 publications with MYC and CDKN2A
 CDK4 antibody  >352 publications with MYC and CDK4
 RB1 antibody  >163 publications with MYC and RB1
 AKT1 antibody  >148 publications with MYC and AKT1
 KAT2A antibody  >9 publications with MYC and KAT2A

Pathways associated with anti-MYC antibody

 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Association Between Physico-Chemical Features And Toxicity Associated Pathways antibodies  Association Between Physico-Chemical Features And Toxicity Associated Pathways Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Binding Of TCF/LEF:CTNNB1 To Target Gene Promoters Pathway antibodies  Binding Of TCF/LEF:CTNNB1 To Target Gene Promoters Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram

Diseases associated with anti-MYC antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4792 publications with MYC and Carcinoma
 Neuroectodermal Tumors Antibodies  >3048 publications with MYC and Neuroectodermal Tumors
 Cell Transformation, Neoplastic Antibodies  >2919 publications with MYC and Cell Transformation, Neoplastic
 Neuroblastoma Antibodies  >2164 publications with MYC and Neuroblastoma
 Adenocarcinoma Antibodies  >2143 publications with MYC and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >1644 publications with MYC and Neoplasms, Experimental
 Disease Progression Antibodies  >1533 publications with MYC and Disease Progression
 Liver Neoplasms Antibodies  >1362 publications with MYC and Liver Neoplasms
 Lung Neoplasms Antibodies  >1169 publications with MYC and Lung Neoplasms
 Burkitt Lymphoma Antibodies  >1097 publications with MYC and Burkitt Lymphoma

Organs/Tissues associated with anti-MYC antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4327 publications with MYC and Blood
 Liver Antibodies  >2413 publications with MYC and Liver
 Lung Antibodies  >1832 publications with MYC and Lung
 Bone Antibodies  >1715 publications with MYC and Bone
 Brain Antibodies  >1537 publications with MYC and Brain
 Muscle Antibodies  >1314 publications with MYC and Muscle
 Bone Marrow Antibodies  >1179 publications with MYC and Bone Marrow
 Vascular Antibodies  >1132 publications with MYC and Vascular
 Prostate Antibodies  >1003 publications with MYC and Prostate
 Kidney Antibodies  >976 publications with MYC and Kidney
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