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TRAIL R3/TNFRSF10C Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200472

TNFRSF10C also known as tumor necrosis factor receptor superfamily member 10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TRAIL R3/TNFRSF10C, Monoclonal Antibody
Full Product Name
TRAIL R3/TNFRSF10C
Product Synonym Names
Tumor necrosis factor receptor superfamily member 10C; Tumor necrosis factor receptor superfamily member 10C; CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
AT1E12
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Purity/Purification
Protein-A Affinity Chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.
OMIM
603613
3D Structure
ModBase 3D Structure for O14798
Immunogen
Recombinant human TNFRSF10C (26-236aa) purified from E Coli.
Conjugation
Unconjugated

Product Categories/Family for anti-TRAIL R3/TNFRSF10C antibody

Applications Tested/Suitable for anti-TRAIL R3/TNFRSF10C antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Immunocytochemistry/Immunofluorescence (ICC/IF) of anti-TRAIL R3/TNFRSF10C antibody

ICC/IF analysis of TNFRSF10C in HeLa cells. The cell was stained (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
Mouse Anti-TRAIL R3/TNFRSF10C Monoclonal Antibody – Cat# MBS200472

Western Blot (WB) of anti-TRAIL R3/TNFRSF10C antibody

The tissue lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TNFRFS10C antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Liver tissue lysate
Mouse Anti-TRAIL R3/TNFRSF10C Monoclonal Antibody, Western Blot (WB) – Cat# MBS200472

Product References and Citations for anti-TRAIL R3/TNFRSF10C antibody

Venza M., et al. (2013) Biochem. Biophys. Res. Commun. 441 (4), 743-750.

Other Notes

Small volumes of anti-TRAIL R3/TNFRSF10C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRAIL R3/TNFRSF10C purchase

MBS200472 is an antibody targeting TRAIL R3/TNFRSF10C. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TRAIL R3/TNFRSF10C. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
Tumor necrosis factor receptor superfamily member 10C
NCBI Official Synonym Full Names
TNF receptor superfamily member 10c
NCBI Official Symbol
TNFRSF10C
NCBI Official Synonym Symbols
LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10C
UniProt Synonym Protein Names
Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD_antigen: CD263
UniProt Gene Name
TNFRSF10C
UniProt Synonym Gene Names
DCR1; LIT; TRAILR3; TRID; DcR1; TRAIL receptor 3; TRAIL-R3
UniProt Entry Name
TR10C_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10C

NCBI Summary for TRAIL R3/TNFRSF10C

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
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UniProt Comments for TRAIL R3/TNFRSF10C

TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: integral to plasma membrane

Molecular Function: transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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