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NKp46/NCR1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200489

A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel Nk… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NKp46/NCR1, Monoclonal Antibody
Full Product Name
NKp46/NCR1
Product Gene Name
Product Synonym Names
Natural cytotoxicity triggering receptor 1 isoform a; NCR1; LY94; NCR; NKp46 Extracellular Ig-like domain; Natural killer cell p46-related protein; hNKp46; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335 antigen; Natural cytotoxicity triggering receptor 1; Natural cytotoxicity triggering receptor 1 isoform a
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
n1D9
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.
OMIM
604530
3D Structure
ModBase 3D Structure for O76036
Immunogen
Recombinant human Nkp46/NCR1 (22-255aa) purified from E Coli.
Conjugation
Unconjugated
Applications Tested/Suitable for anti-NKp46/NCR1 antibody
ELISA (EIA), Flow Cytometry (FC/FACS)

Flow Cytometry (FC/FACS) of anti-NKp46/NCR1 antibody

Flow cytometry analysis of NKp46/NCR1 in PBMC. The cell was stained at 2-5ug for 1x10^6cells (red). A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray).
Mouse Anti-NKp46/NCR1 Monoclonal Antibody – Cat# MBS200489

Product References and Citations for anti-NKp46/NCR1 antibody

Sivori, S. et al., (1997) J. Exp. Med. 186:1125-36. Pessino, A. et al., (1998) J. Exp. Med. 188:953-60.

Other Notes

Small volumes of anti-NKp46/NCR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKp46/NCR1 purchase

MBS200489 is an antibody targeting NKp46/NCR1. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NKp46/NCR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI Accession #
UniProt Primary Accession #
GenBank Nucleotide #
NCBI Official Full Name
natural cytotoxicity triggering receptor 1 isoform b
UniProt Protein Name
Natural cytotoxicity triggering receptor 1
UniProt Synonym Protein Names
Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein
UniProt Gene Name
NCR1
UniProt Synonym Gene Names
LY94; NK-p46; NKp46; hNKp46
UniProt Entry Name
NCTR1_HUMAN

UniProt Comments for NKp46/NCR1

NCR1: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Apoptosis; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: SWI/SNF complex; integral to plasma membrane

Molecular Function: receptor signaling protein activity

Biological Process: regulation of natural killer cell mediated cytotoxicity; cellular defense response; natural killer cell activation; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NKp46/NCR1 antibody

 Reference Product  PubMed Publications
 CD59 antibody  >1 publications with NKp46/NCR1 and CD59
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