Superoxide Dismutase 2, Mitochondrial (SOD2) Antibody – Rabbit Polyclonal

SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.15.1.1; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q11

Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; myelin sheath

Molecular Function: DNA binding; enzyme binding; identical protein binding; manganese ion binding; oxidoreductase activity; oxygen binding; superoxide dismutase activity

Biological Process: acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to oxidative stress; age-dependent response to reactive oxygen species; aging; apoptotic mitochondrial changes; detection of oxygen; DNA damage response, signal transduction resulting in induction of apoptosis; erythrophore differentiation; glutathione metabolic process; heart development; hemopoiesis; hydrogen peroxide biosynthetic process; hydrogen peroxide metabolic process; induction of apoptosis by oxidative stress; iron ion homeostasis; liver development; locomotory behavior; mitochondrion organization; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of fibroblast proliferation; negative regulation of neuron apoptosis; neuron development; oxygen homeostasis; positive regulation of cell migration; positive regulation of nitric oxide biosynthetic process; post-embryonic development; protein homooligomerization; protein homotetramerization; regulation of blood pressure; regulation of catalytic activity; regulation of mitochondrial membrane potential; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; response to activity; response to axon injury; response to cadmium ion; response to cold; response to drug; response to electrical stimulus; response to gamma radiation; response to hydrogen peroxide; response to hyperoxia; response to hypoxia; response to L-ascorbic acid; response to lipopolysaccharide; response to manganese ion; response to nutrient levels; response to oxidative stress; response to radiation; response to reactive oxygen species; response to selenium ion; response to silicon dioxide; response to superoxide; response to zinc ion; sensory perception of sound; superoxide anion generation; superoxide metabolic process; vasodilation