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Collagen Type XIV (COL14) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2006403
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MBS2006403 is an antibody targeting COL14. Also known as Polyclonal Antibody to Collagen Type XIV (COL14). Reactive in Human, Pig. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Collagen Type XIV (COL14), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Collagen Type XIV (COL14)
Product Gene Name
anti-COL14 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Pig
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
500ug/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4ºC for frequent use.
Aliquot and store at -20ºC for 24 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: COL14 (MBS2006403)
Immunogen: COL14 (MBS2011757)
Matching Pairs
Unconjugated Antibody: COL14 (MBS2006403)
APC-CY7 Conjugated Antibody: COL14 (MBS2070171)
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Molecular Weight
183,154 Da
OMIM
AC020603 Genomic DNA
3D Structure
ModBase 3D Structure for Q05707
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Organism Species
Homo sapiens (Human)
Source
Polyclonal antibody preparation
Traits
Liquid
Cross Reactivity
Human
Immunogen
Recombinant COL14 (Glu1280~Leu1461) expressed in E.coli
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-COL14 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunohistochemistry (ICC), Immunoprecipirtation (IP).
Application Notes for anti-COL14 antibody
Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-COL14 antibody

Western Blot; Sample: Recombinant COL14, Human.
Rabbit Anti-COL14 Polyclonal Antibody – Cat# MBS2006403

Immunohistochemistry (IHC) of anti-COL14 antibody

DAB staining on IHC-P
Samples: Human Cardiac Muscle Tissue
Primary Ab: 20ug/ml Rabbit Anti-Human COL14 Antibody
Second Ab: 2ug/mL HRPLinked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-COL14 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2006403

Other Notes

Small volumes of anti-COL14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COL14. It may not necessarily be applicable to this product.

NCBI GI #
55743096
NCBI GeneID
7373
NCBI Accession #
NP_066933.1
UniProt Primary Accession #
Q05707
UniProt Secondary Accession #
O00260; O00261; O00262; Q05708; Q5XJ18; Q96C67; Q9UDF6; B2RU07
UniProt Related Accession #
Q05707
GenBank Nucleotide #
NM_021110.3
NCBI Official Full Name
collagen alpha-1(XIV) chain
NCBI Official Synonym Full Names
collagen type XIV alpha 1 chain
NCBI Official Symbol
COL14A1
NCBI Official Synonym Symbols
UND
UniProt Protein Name
Collagen alpha-1(XIV) chain
UniProt Synonym Protein Names
Undulin
Protein Family
Zinc finger protein CONSTANS
UniProt Gene Name
COL14A1
NCBI Protein Information
collagen alpha-1(XIV) chain

NCBI Summary for COL14

This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]

UniProt Comments for COL14

COL14A1: Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q24.12

Cellular Component: collagen; collagen type XIV; endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: collagen binding; extracellular matrix structural constituent; protein binding, bridging; RNA binding

Biological Process: collagen fibril organization; extracellular matrix organization
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Research Articles on COL14

1. the intima+media of IPAH vessels, collagens (COL4A5, COL14A1, and COL18A1), matrix metalloproteinase (MMP) 19, and a disintegrin and metalloprotease (ADAM) 33 were higher expressed, whereas MMP10, ADAM17, TIMP1, and TIMP3 were less abundant.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COL14 antibody

 Reference Product  PubMed Publications
 DCN antibody  >2 publications with COL14 and DCN
 CD44 antibody  >2 publications with COL14 and CD44

Pathways associated with anti-COL14 antibody

 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram

Diseases associated with anti-COL14 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >12 publications with COL14 and Fibrosis
 Neoplasms Antibodies  >6 publications with COL14 and Neoplasms
 Liver Diseases Antibodies  >6 publications with COL14 and Liver Diseases
 Inflammation Antibodies  >4 publications with COL14 and Inflammation
 Kidney Diseases Antibodies  >3 publications with COL14 and Kidney Diseases
 Hyperplasia Antibodies  >2 publications with COL14 and Hyperplasia
 Hemorrhage Antibodies  >1 publications with COL14 and Hemorrhage
 Pancreatic Neoplasms Antibodies  >1 publications with COL14 and Pancreatic Neoplasms
 Breast Neoplasms Antibodies  >1 publications with COL14 and Breast Neoplasms
 Atherosclerosis Antibodies  >1 publications with COL14 and Atherosclerosis

Organs/Tissues associated with anti-COL14 antibody

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >20 publications with COL14 and Connective Tissue
 Embryonic Tissue Antibodies  >11 publications with COL14 and Embryonic Tissue
 Skin Antibodies  >10 publications with COL14 and Skin
 Liver Antibodies  >9 publications with COL14 and Liver
 Vascular Antibodies  >9 publications with COL14 and Vascular
 Muscle Antibodies  >8 publications with COL14 and Muscle
 Placenta Antibodies  >4 publications with COL14 and Placenta
 Bone Antibodies  >3 publications with COL14 and Bone
 Bone Marrow Antibodies  >2 publications with COL14 and Bone Marrow
 Kidney Antibodies  >2 publications with COL14 and Kidney
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