Permeability Glycoprotein (PGP) Antibody – Rabbit Polyclonal

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.

Protein type: Cell adhesion; EC 3.6.3.44; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 7q21.12

Cellular Component: apical plasma membrane; cell surface; extracellular exosome; integral component of membrane; membrane; plasma membrane

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; ceramide-translocating ATPase activity; phosphatidylcholine-translocating ATPase activity; phosphatidylethanolamine-translocating ATPase activity; protein binding; transporter activity; xenobiotic transmembrane transporting ATPase activity

Biological Process: ceramide translocation; drug transmembrane transport; G2/M transition of mitotic cell cycle; phospholipid translocation; positive regulation of anion channel activity; regulation of chloride transport; regulation of response to osmotic stress; response to drug; stem cell proliferation; transmembrane transport; transport; xenobiotic transport

Disease: Colchicine Resistance; Inflammatory Bowel Disease 13