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C-Type Natriuretic Peptide (CNP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2006572
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MBS2006572 is an antibody targeting CNP. Also known as Polyclonal Antibody to C-Type Natriuretic Peptide (CNP). Reactive in Human, Mouse. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C-Type Natriuretic Peptide (CNP), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to C-Type Natriuretic Peptide (CNP)
Product Gene Name
anti-CNP antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- RTPPAEEL AEPQAAGGGQ KKGDKAPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS MSGLG
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
0.93mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against CNP. It has been selected for its ability to recognize CNP in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: CNP (MBS2006572)
Immunogen: CNP (MBS2010082)
Matching Pairs
Unconjugated Antibody: CNP (MBS2006572)
APC-CY7 Conjugated Antibody: CNP (MBS2046561)
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Molecular Weight
13,246 Da
OMIM
M64710 Genomic DNA
3D Structure
ModBase 3D Structure for P23582
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant CNP (Arg33~Gly125) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2046563
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CNP antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-CNP antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-CNP antibody

Western Blot: Sample: Human Lung lysate; Primary Ab: 1ug/ml Rabbit Anti-Human CNP Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-CNP Polyclonal Antibody – Cat# MBS2006572

Western Blot (WB) of anti-CNP antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-CNP Polyclonal Antibody, Western Blot (WB) – Cat# MBS2006572

Immunohistochemistry (IHC) of anti-CNP antibody

DAB staining on IHC-P; Samples: Human Liver Tissue)
Rabbit Anti-CNP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2006572

Other Notes

Small volumes of anti-CNP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNP. It may not necessarily be applicable to this product.

NCBI GI #
13249346
NCBI GeneID
4880
NCBI Accession #
NP_077720.1
UniProt Primary Accession #
P23582
UniProt Secondary Accession #
Q4ZG41
UniProt Related Accession #
P23582
GenBank Nucleotide #
NM_024409.3
NCBI Official Full Name
C-type natriuretic peptide preproprotein
NCBI Official Synonym Full Names
natriuretic peptide C
NCBI Official Symbol
NPPC
NCBI Official Synonym Symbols
CNP; CNP2
UniProt Protein Name
C-type natriuretic peptide
Protein Family
2',3'-cyclic-nucleotide 3'-phosphodiesterase
UniProt Gene Name
NPPC
UniProt Synonym Gene Names
CNP2
NCBI Protein Information
C-type natriuretic peptide

NCBI Summary for CNP

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
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UniProt Comments for CNP

NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: extracellular region; extracellular space; protein complex; secretory granule

Molecular Function: hormone activity; peptide hormone receptor binding; protein homodimerization activity; receptor binding

Biological Process: cGMP biosynthetic process; negative regulation of cell proliferation; negative regulation of DNA metabolic process; negative regulation of meiotic cell cycle; ossification; positive regulation of cGMP biosynthetic process; positive regulation of osteoblast differentiation; post-embryonic development; protein folding; receptor guanylyl cyclase signaling pathway; regulation of cAMP metabolic process; regulation of cGMP metabolic process; regulation of multicellular organism growth; regulation of smooth muscle cell proliferation; response to drug; response to ethanol; response to hypoxia
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Research Articles on CNP

1. CNP level in pericardial fluid is a more sensitive marker of LV dysfunction than CNP levels in plasma in coronary artery disease patients undergoing coronary artery bypass grafting.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNP antibody

 Reference Product  PubMed Publications
 NPR2 antibody  >14 publications with CNP and NPR2
 NPPA antibody  >6 publications with CNP and NPPA
 NPR3 antibody  >5 publications with CNP and NPR3
 NPPB antibody  >4 publications with CNP and NPPB
 NPR1 antibody  >3 publications with CNP and NPR1

Diseases associated with anti-CNP antibody

 Disease Name  Pubmed Publications
 Bone Diseases, Developmental Antibodies  >6 publications with CNP and Bone Diseases, Developmental
 Nervous System Diseases Antibodies  >5 publications with CNP and Nervous System Diseases
 Growth Disorders Antibodies  >3 publications with CNP and Growth Disorders
 Heart Diseases Antibodies  >2 publications with CNP and Heart Diseases
 Cardiovascular Diseases Antibodies  >2 publications with CNP and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >2 publications with CNP and Disease Models, Animal
 Hypertrophy Antibodies  >2 publications with CNP and Hypertrophy
 Cartilage Diseases Antibodies  >2 publications with CNP and Cartilage Diseases
 Hypertension Antibodies  >1 publications with CNP and Hypertension
 Kidney Diseases Antibodies  >1 publications with CNP and Kidney Diseases

Organs/Tissues associated with anti-CNP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with CNP and Brain
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