Parkinson Disease Protein 7 (PARK7) Antibody – Rabbit Polyclonal

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration.

Protein type: EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: axon; cell body; cell-cell adherens junction; chromatin; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane raft; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; PML body; presynapse

Molecular Function: androgen receptor binding; cadherin binding; copper ion binding; cytokine binding; double-stranded DNA binding; enzyme binding; identical protein binding; kinase binding; L-dopa decarboxylase activator activity; mercury ion binding; mRNA binding; oxidoreductase activity, acting on peroxide as acceptor; peptidase activity; peroxiredoxin activity; protein binding; protein deglycase activity; protein homodimerization activity; receptor binding; single-stranded DNA binding; small protein activating enzyme binding; superoxide dismutase copper chaperone activity; transcription coactivator activity; transcription factor binding; tyrosine 3-monooxygenase activator activity; ubiquitin-like protein conjugating enzyme binding; ubiquitin-specific protease binding

Biological Process: activation of protein kinase B activity; adult locomotory behavior; autophagy; cellular oxidant detoxification; cellular response to glyoxal; cellular response to hydrogen peroxide; cellular response to oxidative stress; detoxification of copper ion; detoxification of mercury ion; DNA repair; dopamine uptake; enzyme active site formation via L-cysteine sulfinic acid; glucose homeostasis; glutathione deglycation; glycolate biosynthetic process; guanine deglycation; guanine deglycation, glyoxal removal; guanine deglycation, methylglyoxal removal; hydrogen peroxide metabolic process; inflammatory response; insulin secretion; lactate biosynthetic process; membrane depolarization; membrane hyperpolarization; methylglyoxal metabolic process; mitochondrion organization; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of gene expression; negative regulation of neuron apoptosis; negative regulation of neuron death; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein export from nucleus; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of ubiquitin-protein ligase activity; negative regulation of ubiquitin-specific protease activity; peptidyl-arginine deglycation; peptidyl-cysteine deglycation; peptidyl-lysine deglycation; positive regulation of acute inflammatory response to antigenic stimulus; positive regulation of androgen receptor activity; positive regulation of gene expression; positive regulation of interleukin-8 production; positive regulation of NAD(P)H oxidase activity; positive regulation of oxidative phosphorylation uncoupler activity; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein homodimerization activity; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of superoxide dismutase activity; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription regulatory region DNA binding; protein deglycation, glyoxal removal; protein deglycation, methylglyoxal removal; protein deglycosylation; protein stabilization; proteolysis; Ras protein signal transduction; regulation of inflammatory response; regulation of mitochondrial membrane potential; regulation of neuron apoptosis; regulation of TRAIL receptor biosynthetic process; single fertilization

Disease: Parkinson Disease 7, Autosomal Recessive Early-onset