Myosin Heavy Chain 11, Smooth Muscle (MYH11) Antibody – Rabbit Polyclonal

MYH11: Muscle contraction. A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11. Defects in MYH11 are the cause of familial aortic aneurysm thoracic type 4 (AAT4); also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor; Oncoprotein

Chromosomal Location of Human Ortholog: 10q11

Cellular Component: brush border; melanosome; muscle myosin complex; myofibril; myosin complex; smooth muscle contractile fiber; stress fiber

Molecular Function: actin binding; ATP binding; calmodulin binding; motor activity; structural constituent of muscle

Biological Process: cardiac muscle fiber development; elastic fiber assembly; smooth muscle contraction