Homolog (REV1) Antibody – Rabbit Polyclonal

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008]

REV1L: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Belongs to the DNA polymerase type-Y family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; DNA repair, damage; EC 2.7.7.-

Chromosomal Location of Human Ortholog: 2q11.1-q11.2

Cellular Component: nucleoplasm

Molecular Function: protein binding; magnesium ion binding; DNA-directed DNA polymerase activity; damaged DNA binding; deoxycytidyl transferase activity

Biological Process: error-prone postreplication DNA repair; DNA replication; DNA repair; response to UV