Prostaglandin Endoperoxide Synthase 2 (PTGS2) Antibody – Rabbit Polyclonal

This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]

COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family.

Protein type: EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 1 G1|1 63.84 cM

Cellular Component: caveola; cytoplasm; endoplasmic reticulum; intracellular membrane-bound organelle; membrane; neuron projection; nucleus; protein complex

Molecular Function: dioxygenase activity; enzyme binding; heme binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peroxidase activity; prostaglandin-endoperoxide synthase activity; protein homodimerization activity

Biological Process: anagen; angiogenesis; bone mineralization; brown fat cell differentiation; cyclooxygenase pathway; decidualization; embryo implantation; fatty acid biosynthetic process; fatty acid metabolic process; inflammatory response; keratinocyte differentiation; learning; lipid metabolic process; memory; negative regulation of apoptosis; negative regulation of calcium ion transport; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of smooth muscle contraction; negative regulation of synaptic transmission, dopaminergic; ovulation; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of fever; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of prostaglandin biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; positive regulation of vasoconstriction; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of blood pressure; regulation of cell proliferation; response to cytokine; response to lipopolysaccharide; response to oxidative stress; sensory perception of pain