Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2) Antibody – Rabbit Polyclonal

TNIP2: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 5|5 B2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; protein kinase binding

Biological Process: apoptosis; I-kappaB kinase/NF-kappaB signaling; inflammatory response; positive regulation of B cell activation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of macrophage activation; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of transcription, DNA-templated; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; transcription, DNA-dependent