3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

CD200R1 Active Protein

Name: CD200R1 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS201075
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201075

CD200R1, also known as cell surface glycoprotein CD200 receptor 1 isoform d, is a transmembrane protein in the immunoglobulin superfamily. This glycoprotein contains on C2 type Ig-like domain and V type Ig-like domain within its extracellular domain and a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD200R1, Active Protein

Full Product Name

Recombinant CD200R1

Product Gene Name

CD200R1 active protein

Product Synonym Names

Cell surface glycoprotein CD200 receptor 1 isoform d; CD200R1; CD200R; HCRTR2; MOX2R; OX2R

Sequence

ADLSSSLCMD EKQITQNYSK VLAEVNTSWP VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYKK ETNETKETNC TDERITWVSR PDQNSDLQIR TVAITHDGYY RCIMVTPDGN FHRGYHLQVL VTPEVTLFQN RNRTAVCKAV AGKPAAHISW IPEGDCATKQ EYWSNGTVTV KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH

Host

Baculovirus

Form/Format

Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 10% Glycerol.

Purity/Purification

>90% by SDS-PAGE

Concentration

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.

Molecular Weight

51.9kDa (462aa); 50-70kDa (SDS-PAGE under reducing conditions)

Sequence Positions

24-243aa

OMIM

607546

3D Structure

ModBase 3D Structure for Q8TD46

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Human

Endotoxin

<1.0 EU per 1ug of protein (determined by LAL method)

Tag

hIgG-His-Tag

Predicted N-Terminal

Ala

Product Categories/Family for CD200R1 active protein

Immunology

Applications Tested/Suitable for CD200R1 active protein

SDS-PAGE

Product References and Citations for CD200R1 active protein

Wright GJ., et al, (2003) J. Immunol. 171:3034-3046. Liu JQ., et al, (2016) J. Immunol. 197:1489-1497.

Other Notes

Small volumes of CD200R1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD200R1 purchase

MBS201075 is an active protein targeting CD200R1. Also known as Recombinant CD200R1. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CD200R1. It may not necessarily be applicable to this product.

NCBI GI #

20270365

NCBI GeneID

131450

NCBI Accession #

NP_620161.1

UniProt Primary Accession #

Q8TD46

UniProt Related Accession #

Q8TD46

GenBank Nucleotide #

NP_620161.1

NCBI Official Full Name

cell surface glycoprotein CD200 receptor 1 isoform a

NCBI Official Synonym Full Names

CD200 receptor 1

NCBI Official Symbol

CD200R1

NCBI Official Synonym Symbols

OX2R; MOX2R; CD200R; HCRTR2

UniProt Protein Name

Cell surface glycoprotein CD200 receptor 1

UniProt Synonym Protein Names

CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1

Protein Family

Cell surface glycoprotein CD200 receptor

UniProt Gene Name

CD200R1

UniProt Synonym Gene Names

CD200R; CRTR2; MOX2R; OX2R

UniProt Entry Name

MO2R1_HUMAN

NCBI Protein Information

cell surface glycoprotein CD200 receptor 1

NCBI Summary for CD200R1

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

UniProt Comments for CD200R1

CD200R: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. Belongs to the CD200R family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: integral to membrane; extracellular region; plasma membrane; receptor complex

Molecular Function: protein binding

Biological Process: regulation of immune response; viral reproduction

Research Articles on CD200R1

1. Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD200R1 active protein

Reference Product	PubMed Publications
CD200 active protein	>55 publications with CD200R1 and CD200

Pathways associated with CD200R1 active protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with CD200R1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>14 publications with CD200R1 and Inflammation
Neoplasms Antibodies	>7 publications with CD200R1 and Neoplasms
Necrosis Antibodies	>6 publications with CD200R1 and Necrosis
Disease Models, Animal Antibodies	>6 publications with CD200R1 and Disease Models, Animal
Carcinoma Antibodies	>3 publications with CD200R1 and Carcinoma
Skin Neoplasms Antibodies	>3 publications with CD200R1 and Skin Neoplasms
Breast Neoplasms Antibodies	>1 publications with CD200R1 and Breast Neoplasms
Lupus Erythematosus, Systemic Antibodies	>1 publications with CD200R1 and Lupus Erythematosus, Systemic
Lung Neoplasms Antibodies	>1 publications with CD200R1 and Lung Neoplasms
Hyperplasia Antibodies	>1 publications with CD200R1 and Hyperplasia

Organs/Tissues associated with CD200R1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>32 publications with CD200R1 and Blood
Brain Antibodies	>14 publications with CD200R1 and Brain
Bone Marrow Antibodies	>7 publications with CD200R1 and Bone Marrow
Lung Antibodies	>3 publications with CD200R1 and Lung
Thymus Antibodies	>2 publications with CD200R1 and Thymus
Placenta Antibodies	>2 publications with CD200R1 and Placenta
Liver Antibodies	>1 publications with CD200R1 and Liver
Kidney Antibodies	>1 publications with CD200R1 and Kidney
Connective Tissue Antibodies	>1 publications with CD200R1 and Connective Tissue