3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

CD19 Recombinant Protein

Name: CD19 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS201082
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201082

CD19, also known as B-lymphocyte antigen CD19 isoform 1, is a member of the Ig superfamily expressed on the surface of all B-lymphoid cells with the exception of terminally differentiated plasma cells. It has been implicated as a signal-transducing receptor… More details

$280 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD19, Recombinant Protein

Full Product Name

Recombinant CD19

Product Gene Name

CD19 recombinant protein

Product Synonym Names

B-lymphocyte antigen CD19 isoform 1; CD19; B4; CVID3

Sequence

EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH

Host

Baculovirus

Form/Format

Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 10% Glycerol.

Purity/Purification

>85% by SDS-PAGE

Concentration

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.

Molecular Weight

57.0kDa (510aa); 50-70kDa (SDS-PAGE under reducing conditions)

Sequence Positions

21-291aa

OMIM

107265

3D Structure

ModBase 3D Structure for P15391

Species

Human

Endotoxin

<1.0 EU per 1ug of protein (determined by LAL method)

Tag

hIgG-His-Tag

Predicted N-Terminal

Glu21

Product Categories/Family for CD19 recombinant protein

Immunology

Applications Tested/Suitable for CD19 recombinant protein

SDS-PAGE

Product References and Citations for CD19 recombinant protein

Bradbury LE., et al. (1992) J Immunol. 149:2841-2850. Kozmik Z., et al. (1992) Mol Cell Biol. 12:2662-2672.

Other Notes

Small volumes of CD19 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD19 purchase

MBS201082 is a recombinant protein targeting CD19. Also known as Recombinant CD19. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CD19. It may not necessarily be applicable to this product.

NCBI GI #

296010921

NCBI GeneID

930

NCBI Accession #

NP_001171569.1

UniProt Primary Accession #

P15391

UniProt Related Accession #

P15391

GenBank Nucleotide #

NP_001171569.1

NCBI Official Full Name

B-lymphocyte antigen CD19 isoform 1

NCBI Official Synonym Full Names

CD19 molecule

NCBI Official Symbol

CD19

NCBI Official Synonym Symbols

B4; CVID3

UniProt Protein Name

B-lymphocyte antigen CD19

UniProt Synonym Protein Names

B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12

Protein Family

B-lymphocyte antigen

UniProt Gene Name

CD19

UniProt Entry Name

CD19_HUMAN

NCBI Protein Information

B-lymphocyte antigen CD19

NCBI Summary for CD19

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

UniProt Comments for CD19

CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: protein complex; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: receptor signaling protein activity

Biological Process: epidermal growth factor receptor signaling pathway; B cell receptor signaling pathway; regulation of immune response; cell surface receptor linked signal transduction; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response; positive regulation of release of sequestered calcium ion into cytosol

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3

Research Articles on CD19

1. CD3(+)TCRalphabeta(+) and CD19(+) cell-depleted haploidentical or mMUD HSCT is a practical and viable alternative for children with a range of PIDs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD19 recombinant protein

Reference Product	PubMed Publications
CD22 recombinant protein	>563 publications with CD19 and CD22
CD79A recombinant protein	>134 publications with CD19 and CD79A
CD79B recombinant protein	>99 publications with CD19 and CD79B
CD81 recombinant protein	>89 publications with CD19 and CD81
CD9 recombinant protein	>78 publications with CD19 and CD9
CR2 recombinant protein	>75 publications with CD19 and CR2
LYN recombinant protein	>55 publications with CD19 and LYN
SYK recombinant protein	>40 publications with CD19 and SYK
BTK recombinant protein	>36 publications with CD19 and BTK
VAV1 recombinant protein	>13 publications with CD19 and VAV1

Pathways associated with CD19 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram

Diseases associated with CD19 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2854 publications with CD19 and Neoplasms
Lymphoma Antibodies	>1667 publications with CD19 and Lymphoma
Cardiovascular Diseases Antibodies	>400 publications with CD19 and Cardiovascular Diseases
Inflammation Antibodies	>301 publications with CD19 and Inflammation
Necrosis Antibodies	>293 publications with CD19 and Necrosis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Antibodies	>251 publications with CD19 and Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Arthritis, Rheumatoid Antibodies	>177 publications with CD19 and Arthritis, Rheumatoid
Liver Diseases Antibodies	>147 publications with CD19 and Liver Diseases
Kidney Diseases Antibodies	>126 publications with CD19 and Kidney Diseases
Drug Toxicity Antibodies	>125 publications with CD19 and Drug Toxicity

Organs/Tissues associated with CD19 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5630 publications with CD19 and Blood
Bone Marrow Antibodies	>1613 publications with CD19 and Bone Marrow
Spleen Antibodies	>509 publications with CD19 and Spleen
Lymph Node Antibodies	>439 publications with CD19 and Lymph Node
Lymph Antibodies	>392 publications with CD19 and Lymph
Lung Antibodies	>196 publications with CD19 and Lung
Thymus Antibodies	>167 publications with CD19 and Thymus
Brain Antibodies	>115 publications with CD19 and Brain
Tonsil Antibodies	>112 publications with CD19 and Tonsil
Intestine Antibodies	>95 publications with CD19 and Intestine