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MDL-1/CLEC5A Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201085

CLEC5A, also known as C-type lectin domain family 5 member A isoform 1, is a member of the CTL/CTLD superfamily that have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. It… More details

$365 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MDL-1/CLEC5A, Recombinant Protein
Full Product Name
Recombinant MDL-1/CLEC5A
Product Gene Name
MDL-1/CLEC5A recombinant protein
Product Synonym Names
C-type lectin domain family 5 member A isoform 1; CLEC5A; CLECSF5; MDL-1; MDL1
Sequence
ADLPQIFNKS NDGFTTTRSY GTVSQIFGSS SPSPNGFITT RSYGTVCPKD WEFYQARCFF LSTSESSWNE SRDFCKGKGS TLAIVNTPEK LKFLQDITDA EKYFIGLIYH REEKRWRWIN NSVFNGNVTN QNQNFNCATI GLTKTFDAAS CDISYRRICE KNAKHHHHHH
Host
Baculovirus
Form/Format
Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 20% Glycerol, 1mM DTT.
Purity/Purification
>90% by SDS-PAGE
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.
Molecular Weight
19.5kDa (170aa); 28-40KDa (SDS-PAGE under reducing conditions)
Sequence Positions
28-188aa
OMIM
604987
3D Structure
ModBase 3D Structure for Q9NY25
Species
Human
Endotoxin
<1.0 EU per 1ug of protein (determined by LAL method)
Tag
His-Tag
Predicted N-Terminal
Ala

Product Categories/Family for MDL-1/CLEC5A recombinant protein

Immunology
Applications Tested/Suitable for MDL-1/CLEC5A recombinant protein
SDS-PAGE

SDS-Page of MDL-1/CLEC5A recombinant protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
MDL-1/CLEC5A Recombinant Protein – Cat# MBS201085

Product References and Citations for MDL-1/CLEC5A recombinant protein

Gonzalez-Dominguez E., et al, (2015) J Leukoc Biol. 98:453-466. Chen ST., et al, (2017) Nat Commun. 8:299.

Other Notes

Small volumes of MDL-1/CLEC5A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MDL-1/CLEC5A purchase

MBS201085 is a recombinant protein targeting MDL-1/CLEC5A. Also known as Recombinant MDL-1/CLEC5A. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for MDL-1/CLEC5A. It may not necessarily be applicable to this product.

NCBI GI #
59797971
NCBI GeneID
23601
NCBI Accession #
Q9NY25.1
UniProt Primary Accession #
Q9NY25
UniProt Related Accession #
Q9NY25
NCBI Official Full Name
C-type lectin domain family 5 member A
NCBI Official Synonym Full Names
C-type lectin domain containing 5A
NCBI Official Symbol
CLEC5A
NCBI Official Synonym Symbols
MDL1; MDL-1; CLECSF5
UniProt Protein Name
C-type lectin domain family 5 member A
UniProt Synonym Protein Names
C-type lectin superfamily member 5; Myeloid DAP12-associating lectin 1; MDL-1
UniProt Gene Name
CLEC5A
UniProt Synonym Gene Names
CLECSF5; MDL1; MDL-1
UniProt Entry Name
CLC5A_HUMAN
NCBI Protein Information
C-type lectin domain family 5 member A

NCBI Summary for MDL-1/CLEC5A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
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Research Articles on MDL-1/CLEC5A

1. CLEC5A was highly upregulated in glioblastoma compared to normal brain tissues, which had an opposite relation with the overall patient survival. Downregulation of CLEC5A could inhibit cell proliferation, migration and invasion via promoting apoptosis and G1 arrest.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MDL-1/CLEC5A recombinant protein

 Reference Product  PubMed Publications
 TYROBP recombinant protein  >12 publications with MDL-1/CLEC5A and TYROBP
 TREM1 recombinant protein  >3 publications with MDL-1/CLEC5A and TREM1

Pathways associated with MDL-1/CLEC5A recombinant protein

 Products by Pathway  Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with MDL-1/CLEC5A recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with MDL-1/CLEC5A and Inflammation
 Necrosis Antibodies  >5 publications with MDL-1/CLEC5A and Necrosis
 Disease Models, Animal Antibodies  >4 publications with MDL-1/CLEC5A and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >3 publications with MDL-1/CLEC5A and Cardiovascular Diseases
 Severe Dengue Antibodies  >3 publications with MDL-1/CLEC5A and Severe Dengue
 Nervous System Diseases Antibodies  >2 publications with MDL-1/CLEC5A and Nervous System Diseases
 Skin Diseases Antibodies  >1 publications with MDL-1/CLEC5A and Skin Diseases
 Pneumonia Antibodies  >1 publications with MDL-1/CLEC5A and Pneumonia
 Hematologic Diseases Antibodies  >1 publications with MDL-1/CLEC5A and Hematologic Diseases
 Lung Diseases Antibodies  >1 publications with MDL-1/CLEC5A and Lung Diseases

Organs/Tissues associated with MDL-1/CLEC5A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with MDL-1/CLEC5A and Blood
 Bone Marrow Antibodies  >4 publications with MDL-1/CLEC5A and Bone Marrow
 Brain Antibodies  >3 publications with MDL-1/CLEC5A and Brain
 Eye Antibodies  >1 publications with MDL-1/CLEC5A and Eye
 Connective Tissue Antibodies  >1 publications with MDL-1/CLEC5A and Connective Tissue
 Lung Antibodies  >1 publications with MDL-1/CLEC5A and Lung
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