3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

TFRC Recombinant Protein

Name: TFRC Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS201090
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201090

TFRC, also known as transferrin receptor protein 1, is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. It acts as cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied… More details

$230 / 0.004 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TFRC, Recombinant Protein

Full Product Name

Recombinant TFRC

Product Gene Name

TFRC recombinant protein

Product Synonym Names

Transferrin receptor protein 1 isoform 1; TFRC; CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR

Sequence

ADPLAGTESP VREEPGEDFP AARRLYWDDL KRKLSEKLDS TDFTGTIKLL NENSYVPREA GSQKDENLAL YVENQFREFK LSKVWRDQHF VKIQVKDSAQ NSVIIVDKNG RLVYLVENPG GYVAYSKAAT VTGKLVHANF GTKKDFEDLY TPVNGSIVIV RAGKITFAEK VANAESLNAI GVLIYMDQTK FPIVNAELSF FGHAHLGTGD PYTPGFPSFN HTQFPPSRSS GLPNIPVQTI SRAAAEKLFG NMEGDCPSDW KTDSTCRMVT SESKNVKLTV SNVLKEIKIL NIFGVIKGFV EPDHYVVVGA QRDAWGPGAA KSGVGTALLL KLAQMFSDMV LKDGFQPSRS IIFASWSAGD FGSVGATEWL EGYLSSLHLK AFTYINLDKA VLGTSNFKVS ASPLLYTLIE KTMQNVKHPV TGQFLYQDSN WASKVEKLTL DNAAFPFLAY SGIPAVSFCF CEDTDYPYLG TTMDTYKELI ERIPELNKVA RAAAEVAGQF VIKLTHDVEL NLDYERYNSQ LLSFVRDLNQ YRADIKEMGL SLQWLYSARG DFFRATSRLT TDFGNAEKTD RFVMKKLNDR VMRVEYHFLS PYVSPKESPF RHVFWGSGSH TLPALLENLK LRKQNNGAFN ETLFRNQLAL ATWTIQGAAN ALSGDVWDID NEFHHHHHH

Host

Baculovirus

Form/Format

Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 10% Glycerol.

Purity/Purification

>90% by SDS-PAGE

Concentration

0.5mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.

Molecular Weight

74.9kDa (669aa); 70-100KDa (SDS-PAGE under reducing conditions)

Sequence Positions

101-760aa

OMIM

190010

3D Structure

ModBase 3D Structure for P02786

Species

Human

Endotoxin

<1.0 EU per 1ug of protein (determined by LAL method)

Tag

His-Tag

Predicted N-Terminal

Ala

Product Categories/Family for TFRC recombinant protein

Cardiovascular

Applications Tested/Suitable for TFRC recombinant protein

SDS-PAGE

Product References and Citations for TFRC recombinant protein

Laube F., et al, (2017) Anticancer Res. 37:3001-3007. Zhou JH., et al, (2017) J Neurosci. 37:11335-11352.

Other Notes

Small volumes of TFRC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFRC purchase

MBS201090 is a recombinant protein targeting TFRC. Also known as Recombinant TFRC. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for TFRC. It may not necessarily be applicable to this product.

NCBI GI #

189458819

NCBI GeneID

7037

NCBI Accession #

NP_001121620.1

UniProt Primary Accession #

P02786

UniProt Related Accession #

P02786

GenBank Nucleotide #

NP_001121620.1

NCBI Official Full Name

transferrin receptor protein 1 isoform 1

NCBI Official Synonym Full Names

transferrin receptor

NCBI Official Symbol

TFRC

NCBI Official Synonym Symbols

T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46

UniProt Protein Name

Transferrin receptor protein 1

UniProt Synonym Protein Names

T9; p90

Protein Family

Transferrin receptor protein

UniProt Gene Name

TFRC

UniProt Synonym Gene Names

TR; TfR; TfR1; Trfr; sTfR

UniProt Entry Name

TFR1_HUMAN

NCBI Protein Information

transferrin receptor protein 1

NCBI Summary for TFRC

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

UniProt Comments for TFRC

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; vesicle; endosome; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding

Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; positive regulation of bone resorption; transferrin transport; osteoclast differentiation; regulation of cell growth; transmembrane transport; regulation of cell proliferation

Research Articles on TFRC

1. The combination treatment with GA and vorinostat synergistically reduced cell survival in the MYCN and CD71 overexpressing tumor cells. The same treatment had no effect or minimal effect on HEK293 and HEF cells used as models of non-cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TFRC recombinant protein

Reference Product	PubMed Publications
HFE recombinant protein	>18 publications with TFRC and HFE
CD4 recombinant protein	>1 publications with TFRC and CD4

Pathways associated with TFRC recombinant protein

Products by Pathway	Pathway Diagram
Clathrin Derived Vesicle Budding Pathway antibodies	Clathrin Derived Vesicle Budding Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies	FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
Golgi Associated Vesicle Biogenesis Pathway antibodies	Golgi Associated Vesicle Biogenesis Pathway Diagram
HIF-1 Signaling Pathway antibodies	HIF-1 Signaling Pathway Diagram
HIF-1-alpha Transcription Factor Network Pathway antibodies	HIF-1-alpha Transcription Factor Network Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Iron Metabolism In Placenta Pathway antibodies	Iron Metabolism In Placenta Pathway Diagram

Diseases associated with TFRC recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>33 publications with TFRC and Neoplasms
Iron Metabolism Disorders Antibodies	>28 publications with TFRC and Iron Metabolism Disorders
Anemia Antibodies	>16 publications with TFRC and Anemia
Disease Models, Animal Antibodies	>11 publications with TFRC and Disease Models, Animal
Anemia, Iron-Deficiency Antibodies	>8 publications with TFRC and Anemia, Iron-Deficiency
Lung Neoplasms Antibodies	>7 publications with TFRC and Lung Neoplasms
Liver Diseases Antibodies	>6 publications with TFRC and Liver Diseases
Brain Diseases Antibodies	>5 publications with TFRC and Brain Diseases
Breast Neoplasms Antibodies	>4 publications with TFRC and Breast Neoplasms
Drug Toxicity Antibodies	>4 publications with TFRC and Drug Toxicity

Organs/Tissues associated with TFRC recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>34 publications with TFRC and Blood
Liver Antibodies	>22 publications with TFRC and Liver
Brain Antibodies	>16 publications with TFRC and Brain
Intestine Antibodies	>11 publications with TFRC and Intestine
Lung Antibodies	>10 publications with TFRC and Lung
Bone Antibodies	>8 publications with TFRC and Bone
Skin Antibodies	>7 publications with TFRC and Skin
Kidney Antibodies	>7 publications with TFRC and Kidney
Embryonic Tissue Antibodies	>6 publications with TFRC and Embryonic Tissue
Prostate Antibodies	>5 publications with TFRC and Prostate