3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

PDCD4 Recombinant Protein

Name: PDCD4 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS201098
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201098

PDCD4, also known as Programmed cell death 4, encodes a tumor suppressor protein whose expression is lost in progressed carcinomas of lung, breast, colon, and prostate. The expression of PDCD4 gene is strongly induced during apoptosis in a number of cell… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDCD4, Recombinant Protein

Full Product Name

Recombinant PDCD4

Product Gene Name

PDCD4 recombinant protein

Product Synonym Names

Programmed cell death protein 4 isoform 1; H731

Sequence

MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASSI NEARINAKAK RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ MKRGYERIYN EIPDINLDVP HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY

Host

E Coli

Form/Format

Liquid; In 20mM Tris-HCl (pH8.0) Containing 0.1M NaCl, 1mM DTT.

Purity/Purification

>90% by SDS-PAGE

Concentration

1mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.

Molecular Weight

51.7kDa (469 aa)

Sequence Positions

1-469aa

OMIM

608610

3D Structure

ModBase 3D Structure for Q53EL6

Species

Human

Tag

His-Tag

Product Categories/Family for PDCD4 recombinant protein

Cancer; Apoptosis; Cell Cycle; Epigenomics (Transcription & Translation)

Applications Tested/Suitable for PDCD4 recombinant protein

SDS-PAGE

Product References and Citations for PDCD4 recombinant protein

Yoshinaga H., et al. (1999) Pathol lnt. 49(12):1067-77. Palamarchuk A., et al. (2005) Cancer Res. 65(24):11282-6.

Other Notes

Small volumes of PDCD4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDCD4 purchase

MBS201098 is a recombinant protein targeting PDCD4. Also known as Recombinant PDCD4. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PDCD4. It may not necessarily be applicable to this product.

NCBI GI #

21735596

NCBI GeneID

27250

NCBI Accession #

NP_055271.2

UniProt Primary Accession #

Q53EL6

UniProt Related Accession #

Q53EL6

GenBank Nucleotide #

NP_055271.2

NCBI Official Full Name

programmed cell death protein 4 isoform 1

NCBI Official Synonym Full Names

programmed cell death 4

NCBI Official Symbol

PDCD4

NCBI Official Synonym Symbols

H731

UniProt Protein Name

Programmed cell death protein 4

UniProt Synonym Protein Names

Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a

Protein Family

Programmed cell death protein

UniProt Gene Name

PDCD4

UniProt Synonym Gene Names

H731

UniProt Entry Name

PDCD4_HUMAN

NCBI Protein Information

programmed cell death protein 4

NCBI Summary for PDCD4

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

UniProt Comments for PDCD4

PDCD4: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified.

Protein type: Tumor suppressor; Apoptosis

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; RNA binding

Biological Process: negative regulation of JNK activity; apoptosis; cell aging; negative regulation of transcription, DNA-dependent; negative regulation of cell cycle

Research Articles on PDCD4

1. LINC-PINT functions as a tumour-suppressor that exerts important regulatory roles in NSCLC progression by sponging miR-208a-3p/PDCD4

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDCD4 recombinant protein

Reference Product	PubMed Publications
RPS13 recombinant protein	>1 publications with PDCD4 and RPS13
RPL5 recombinant protein	>1 publications with PDCD4 and RPL5
EIF4G1 recombinant protein	>1 publications with PDCD4 and EIF4G1

Pathways associated with PDCD4 recombinant protein

Products by Pathway	Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram
MTOR Signaling Pathway antibodies	MTOR Signaling Pathway Diagram

Diseases associated with PDCD4 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>179 publications with PDCD4 and Neoplasms
Carcinoma Antibodies	>80 publications with PDCD4 and Carcinoma
Cell Transformation, Neoplastic Antibodies	>35 publications with PDCD4 and Cell Transformation, Neoplastic
Neoplasm Metastasis Antibodies	>32 publications with PDCD4 and Neoplasm Metastasis
Neoplasm Invasiveness Antibodies	>26 publications with PDCD4 and Neoplasm Invasiveness
Lung Neoplasms Antibodies	>18 publications with PDCD4 and Lung Neoplasms
Liver Neoplasms Antibodies	>16 publications with PDCD4 and Liver Neoplasms
Inflammation Antibodies	>16 publications with PDCD4 and Inflammation
Neoplasms, Experimental Antibodies	>16 publications with PDCD4 and Neoplasms, Experimental
Liver Diseases Antibodies	>15 publications with PDCD4 and Liver Diseases

Organs/Tissues associated with PDCD4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>27 publications with PDCD4 and Lung
Liver Antibodies	>24 publications with PDCD4 and Liver
Blood Antibodies	>23 publications with PDCD4 and Blood
Muscle Antibodies	>18 publications with PDCD4 and Muscle
Lymph Antibodies	>16 publications with PDCD4 and Lymph
Lymph Node Antibodies	>16 publications with PDCD4 and Lymph Node
Skin Antibodies	>16 publications with PDCD4 and Skin
Brain Antibodies	>15 publications with PDCD4 and Brain
Prostate Antibodies	>12 publications with PDCD4 and Prostate
Vascular Antibodies	>11 publications with PDCD4 and Vascular