3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

Cathepsin X/Z/P (CTSZ) Active Protein

Name: CTSZ Active Protein; Cathepsin X/Z/P; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS201142
Price: 325 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201142

Cathepsin X/Z/P, also known as cathepsin Z/X, is a relatively new cysteine protease of the papain family. Compared to other members of the papain family, It has a short proregion and unique insertions. Acting as a carboxypeptidase, It displays a unique… More details

$325 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cathepsin X/Z/P (Ctsz), Active Protein

Full Product Name

Recombinant Cathepsin X/Z/P

Product Gene Name

Ctsz active protein

Product Synonym Names

Cathepsin X/Z/P; CTSZ; AI787083; AU019819; CTSX; D2Wsu143e

Sequence

ARARLYFRSG QTCYHPIRGD QLALLGRRTY PRPHEYLSPA DLPKNWDWRN VNGVNYASVT RNQHIPQYCG SCWAHGSTSA MADRINIKRK GAWPSILLSV QNVIDCGNAG SCEGGNDLPV WEYAHKHGIP DETCNNYQAK DQDCDKFNQC GTCTEFKECH TIQNYTLWRV GDYGSLSGRE KMMAEIYANG PISCGIMATE MMSNYTGGIY AEHQDQAVIN HIISVAGWGV SNDGIEYWIV RNSWGEPWGE KGWMRIVTST YKGGTGDSYN LAIESACTFG DPIV LEHHHH HH

Host

Baculovirus

Form/Format

Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 10% Glycerol.

Purity/Purification

>95% by SDS-PAGE

Concentration

0.5mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.

Molecular Weight

32.8kDa (292aa); 28-40kDa (SDS-PAGE under reducing conditions)

Sequence Positions

23-306aa

3D Structure

ModBase 3D Structure for Q9WUU7

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Mouse

Endotoxin

<1 EU per 1ug of protein (determined by LAL method)

Tag

His-Tag

Predicted N-Terminal

Ala 23

Biological Activity

Specific activity is > 3,000 pmol/min/ug in which one unit will convert 1.0 pmole of Mca-PLGL-Dpa-AR-NH2 to MCA- Pro-Leu-OH per minute at pH 3.5 at 25C.

Product Categories/Family for Ctsz active protein

Cancer

Applications Tested/Suitable for Ctsz active protein

SDS-PAGE, Enzyme Activity

Product References and Citations for Ctsz active protein

Santamaria., et al. (1998) J. Biol. Chem. 273:16816-16823. Menard., et al. (2001) Biol. Chem. 382:839-845.

Other Notes

Small volumes of Ctsz active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ctsz purchase

MBS201142 is an active protein targeting Ctsz. Also known as Recombinant Cathepsin X/Z/P. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for Ctsz. It may not necessarily be applicable to this product.

NCBI GI #

11968166

NCBI GeneID

64138

NCBI Accession #

NP_071720.1

UniProt Primary Accession #

Q9WUU7

UniProt Related Accession #

Q9WUU7

GenBank Nucleotide #

NP_071720.1

NCBI Official Full Name

cathepsin Z preproprotein

NCBI Official Synonym Full Names

cathepsin Z

NCBI Official Symbol

Ctsz

NCBI Official Synonym Symbols

CTSX; AI787083; AU019819; D2Wsu143e

UniProt Protein Name

Cathepsin Z

Protein Family

Cathepsin

UniProt Gene Name

Ctsz

UniProt Entry Name

CATZ_MOUSE

NCBI Protein Information

cathepsin Z

NCBI Summary for Ctsz

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature enzyme with carboxypeptidase activity. An enzymatically inactive form of the protein, that is associated with the propeptide, may be involved in cancer cell invasion and proliferation. Homozygous knockout mice for this gene exhibit impaired cancer cell invasion in a breast cancer model. [provided by RefSeq, Aug 2015]

UniProt Comments for Ctsz

CTSZ: Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity. Belongs to the peptidase C1 family.

Protein type: EC 3.4.18.1; Protease

Cellular Component: endoplasmic reticulum; extracellular space; intracellular membrane-bound organelle; lysosome

Molecular Function: cysteine-type endopeptidase activity

Biological Process: proteolysis involved in cellular protein catabolic process

Research Articles on Ctsz

1. The data support a novel role for cathepsin Z in the propagation of IL-1beta-driven neuroinflammation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Ctsz active protein

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies	COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
Cargo Concentration In The ER Pathway antibodies	Cargo Concentration In The ER Pathway Diagram
Clathrin Derived Vesicle Budding Pathway antibodies	Clathrin Derived Vesicle Budding Pathway Diagram
ER To Golgi Anterograde Transport Pathway antibodies	ER To Golgi Anterograde Transport Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Vesicle Biogenesis Pathway antibodies	Lysosome Vesicle Biogenesis Pathway Diagram

Diseases associated with Ctsz active protein

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>4 publications with Ctsz and Lung Diseases
Disease Models, Animal Antibodies	>4 publications with Ctsz and Disease Models, Animal
Nervous System Diseases Antibodies	>4 publications with Ctsz and Nervous System Diseases
Death Antibodies	>3 publications with Ctsz and Death
Inflammation Antibodies	>3 publications with Ctsz and Inflammation
Metaplasia Antibodies	>3 publications with Ctsz and Metaplasia
Brain Diseases Antibodies	>2 publications with Ctsz and Brain Diseases
Liver Diseases Antibodies	>2 publications with Ctsz and Liver Diseases
Lung Neoplasms Antibodies	>1 publications with Ctsz and Lung Neoplasms
Kidney Diseases Antibodies	>1 publications with Ctsz and Kidney Diseases

Organs/Tissues associated with Ctsz active protein

Organ/Tissue Name	Pubmed Publications
Other Antibodies	>16 publications with Ctsz and Other
Blood Antibodies	>10 publications with Ctsz and Blood
Brain Antibodies	>7 publications with Ctsz and Brain
Liver Antibodies	>6 publications with Ctsz and Liver
Muscle Antibodies	>5 publications with Ctsz and Muscle
Stomach Antibodies	>3 publications with Ctsz and Stomach
Bone Antibodies	>3 publications with Ctsz and Bone
Lung Antibodies	>2 publications with Ctsz and Lung
Embryonic Tissue Antibodies	>2 publications with Ctsz and Embryonic Tissue
Uterus Antibodies	>2 publications with Ctsz and Uterus