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CD21 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201152

CD21, also known as complement receptor type 2 isoform 2, is an N-glycosylated member of the regulators of complement activation family of proteins. This protein is present on all mature B-cells and some T-cells and follicular dendritic cells and is released… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD21, Recombinant Protein
Full Product Name
Recombinant CD21
Product Gene Name
CD21 recombinant protein
Product Synonym Names
CD21; CR2; Cr2; C3DR; CR; CVID7; SLEB9; Complement receptor type 2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor
Sequence
ISCGSPPPIL NGRISYYSTP IAVGTVIRYS CSGTFRLIGE KSLLCITKDK VDGTWDKPAP KCEYFNKYSS CPEPIVPGGY KIRGSTPYRH GDSVTFACKT NFSMNGNKSV WCQANNMWGP TRLPTCVSVF PLECPALPMI HNGHHTSENV GSIAPGLSVT YSCESGYLLV GEKIINCLSS GKWSAVPPTC EEARCKSLGR FPNGKVKEPP ILRVGVTANF FCDEGYRLQG PPSSRCVIAG QGVAWTKMPV CEEIFCPSPP PILNGRHIGN SLANVSYGSI VTYTCDPDPE EGVNFILIGE STLRCTVDSQ KTGTWSGPAP RCELSTSAVQ CPHPQILRGR MVSGQKDRYT YNDTVIFACM FGFTLKGSKQ IRCNAQGTWE PSAPVCEKEC QAPPNILNGQ KEDRHMVRFD PGTSIKYSCN PGYVLVGEES IQCTSEGVWT PPVPQCKVAA CEATGRQLLT KPQHQFVRPD VNSSCGEGYK LSGSVYQECQ GTIPWFMEIR LCKEITCPPP PVIYNGAHTG SSLEDFPYGT TVTYTCNPGP ERGVEFSLIG ESTIRCTSND QERGTWSGPA PLCKLSLLAV QCSHVHIANG YKISGKEAPY FYNDTVTFKC YSGFTLKGSS QIRCKADNTW DPEIPVCEKE TCQHVRQSLQ ELPAGSRVEL VNTSCQDGYQ LTGHAYQMCQ DAENGIWFKK IPLCKVIHCH PPPVIVNGKH TGMMAENFLY GNEVSYECDQ GFYLLGEKKL QCRSDSKGHG SWSGPSPQCL RSPPVTRCPN PEVKHGYKLN KTHSAYSHND IVYVDCNPGF IMNGSRVIRC HTDNTWVPGV PTCIKKAFIG CPPPPKTPNG NHTGGNIARF SPGMSILYSC DQGYLLVGEA LLLCTHEGTW SQPAPHCKEV NCSSPADMDG IQKGLEPRKM YQYGAVVTLE CEDGYMLEGS PQSQCQSDHQ WNPPLAVCRS R VEHHHHHH
Host
Baculovirus
Form/Format
Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 10% Glycerol.
Purity/Purification
>95% by SDS-PAGE
Concentration
0.5mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.
Molecular Weight
105.2kDa (959aa)
Sequence Positions
21-971aa
OMIM
614699
3D Structure
ModBase 3D Structure for P20023
Species
Human
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Tag
His-Tag
Predicted N-Terminal
Ile 21

Product Categories/Family for CD21 recombinant protein

Immunology
Applications Tested/Suitable for CD21 recombinant protein
SDS-PAGE

SDS-Page of CD21 recombinant protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
CD21 Recombinant Protein – Cat# MBS201152

Product References and Citations for CD21 recombinant protein

Tanner J., et al, (1987) Cell 50:203-213. Carel JC., et al, (1990) J. Biol. Chem. 265:12293.

Other Notes

Small volumes of CD21 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD21 purchase

MBS201152 is a recombinant protein targeting CD21. Also known as Recombinant CD21. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CD21. It may not necessarily be applicable to this product.

NCBI GI #
215273962
NCBI GeneID
1380
NCBI Accession #
P20023.2
UniProt Primary Accession #
P20023
UniProt Related Accession #
P20023
NCBI Official Full Name
Complement receptor type 2
NCBI Official Synonym Full Names
complement C3d receptor 2
NCBI Official Symbol
CR2
NCBI Official Synonym Symbols
CR; C3DR; CD21; CVID7; SLEB9
UniProt Protein Name
Complement receptor type 2
UniProt Synonym Protein Names
Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21
Protein Family
Complement receptor
UniProt Gene Name
CR2
UniProt Synonym Gene Names
C3DR; Cr2; EBV receptor
UniProt Entry Name
CR2_HUMAN
NCBI Protein Information
complement receptor type 2

NCBI Summary for CD21

This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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UniProt Comments for CD21

CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: plasma membrane; integral to membrane; receptor complex; external side of plasma membrane

Molecular Function: complement binding; protein homodimerization activity; transmembrane receptor activity; complement receptor activity; DNA binding

Biological Process: B cell proliferation; complement receptor mediated signaling pathway; B cell differentiation; innate immune response; immune response; complement activation, classical pathway

Disease: Systemic Lupus Erythematosus, Susceptibility To, 9; Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 7
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Research Articles on CD21

1. this study shows CD21 deficiency in 2 siblings with recurrent respiratory infections and hypogammaglobulinemia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD21 recombinant protein

 Reference Product  PubMed Publications
 CR1 recombinant protein  >554 publications with CD21 and CR1
 CD19 recombinant protein  >75 publications with CD21 and CD19
 CD81 recombinant protein  >16 publications with CD21 and CD81
 IFNA17 recombinant protein  >9 publications with CD21 and IFNA17
 NR5A2 recombinant protein  >1 publications with CD21 and NR5A2

Pathways associated with CD21 recombinant protein

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with CD21 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >60 publications with CD21 and Neoplasms, Experimental
 Inflammation Antibodies  >51 publications with CD21 and Inflammation
 Disease Models, Animal Antibodies  >44 publications with CD21 and Disease Models, Animal
 Lupus Erythematosus, Systemic Antibodies  >43 publications with CD21 and Lupus Erythematosus, Systemic
 Cell Transformation, Neoplastic Antibodies  >42 publications with CD21 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >31 publications with CD21 and Necrosis
 Kidney Diseases Antibodies  >19 publications with CD21 and Kidney Diseases
 Liver Diseases Antibodies  >16 publications with CD21 and Liver Diseases
 Lung Diseases Antibodies  >15 publications with CD21 and Lung Diseases
 Brain Diseases Antibodies  >14 publications with CD21 and Brain Diseases

Organs/Tissues associated with CD21 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >638 publications with CD21 and Blood
 Spleen Antibodies  >64 publications with CD21 and Spleen
 Kidney Antibodies  >50 publications with CD21 and Kidney
 Lymph Node Antibodies  >45 publications with CD21 and Lymph Node
 Liver Antibodies  >35 publications with CD21 and Liver
 Brain Antibodies  >30 publications with CD21 and Brain
 Tonsil Antibodies  >25 publications with CD21 and Tonsil
 Lymph Antibodies  >24 publications with CD21 and Lymph
 Vascular Antibodies  >22 publications with CD21 and Vascular
 Thymus Antibodies  >18 publications with CD21 and Thymus
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