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IL-9 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201177

IL-9, also known as interleukin 9, is a cytokine (cell signalling molecule) belonging to the group ofinterleukins. This protein produced by T-cells and specifically by CD4+ helper cells that acts as a regulatorof a variety of hematopoietic cells and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-9, Active Protein
Full Product Name
Recombinant IL-9
Product Gene Name
IL-9 active protein
Product Synonym Names
IL-9; Interleukin-9; HP40; IL9; P40; Cytokine P40; T-cell growth factor P40
Sequence
QGCPTLAGIL DINFLINKMQ EDPASKCHCS ANVTSCLCLG IPSDNCTRPC FSERLSQMTN TTMQTRYPLI FSRVKKSVEV LKNNKCPYFS CEQPCNQTTA GNALTFLKSL LEIFQKEKMR GMRGKI
Host
Baculovirus
Form/Format
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Purity/Purification
> 85% by SDS - PAGE
Concentration
0.5mg/ml (determined by BCA assay) (lot specific)
Preparation and Storage
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoidrepeated freezing and thawing cycles.
Molecular Weight
14.9kDa (132aa);;Multiple bands between 18-28kDa, reducing conditions
Sequence Positions
19-144aa
OMIM
146931
3D Structure
ModBase 3D Structure for P15248
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Tag
His-Tag
Biological Activity
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 range <= 0.3 ng/ml.
Predicted nterm
Gln 19
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for IL-9 active protein

Hormones & Cytokines; Immunology
Applications Tested/Suitable for IL-9 active protein
SDS-PAGE; Bioactivity

SDS-Page of IL-9 active protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
IL-9 Active Protein – Cat# MBS201177

Activity of IL-9 active protein

Human IL-9 stimulates cell proliferation of the MO7e human megakaryocytic leukemic cells. The ED50 range <= 0.3 ng/ml.
IL-9 Active Protein, Activity – Cat# MBS201177

Product References and Citations for IL-9 active protein

Purwar R, Schlapbach C, et al. (2012). Nat Med. 18(8):1248-53. ;;Pilette C, Ouadrhiri Y, et al. (2002). J Immunol. 168(8):4103-11.

Other Notes

Small volumes of IL-9 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-9 purchase

MBS201177 is an active protein targeting IL-9. Also known as Recombinant IL-9. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-9. It may not necessarily be applicable to this product.

NCBI GI #
10834980
NCBI GeneID
3578
NCBI Accession #
NP_000581.1
UniProt Primary Accession #
P15248
UniProt Related Accession #
P15248
GenBank Nucleotide #
NP_000581.1
NCBI Official Full Name
interleukin-9
NCBI Official Synonym Full Names
interleukin 9
NCBI Official Symbol
IL9
NCBI Official Synonym Symbols
P40; HP40; IL-9
UniProt Protein Name
Interleukin-9
UniProt Synonym Protein Names
Cytokine P40; T-cell growth factor P40
UniProt Gene Name
IL9
UniProt Synonym Gene Names
IL-9
UniProt Entry Name
IL9_HUMAN
NCBI Protein Information
interleukin-9

NCBI Summary for IL-9

The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL-9

IL9: Supports IL-2 independent and IL-4 independent growth of helper T-cells. Belongs to the IL-7/IL-9 family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; interleukin-9 receptor binding; cytokine activity

Biological Process: positive regulation of cell proliferation; immune response; inflammatory response; positive regulation of cell growth; positive regulation of interleukin-5 biosynthetic process
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Research Articles on IL-9

1. High IL9 expression is associated with Crohn's disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL-9 active protein

 Reference Product  PubMed Publications
 IL4 active protein  >35 publications with IL-9 and IL4
 IL13 active protein  >22 publications with IL-9 and IL13
 IL5 active protein  >22 publications with IL-9 and IL5
 IL2 active protein  >14 publications with IL-9 and IL2
 IL3 active protein  >11 publications with IL-9 and IL3
 IL7 active protein  >7 publications with IL-9 and IL7
 IL9R active protein  >6 publications with IL-9 and IL9R
 CSF2 active protein  >2 publications with IL-9 and CSF2
 TSLP active protein  >1 publications with IL-9 and TSLP

Pathways associated with IL-9 active protein

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-9 Signaling Pathway antibodies  IL-9 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 TCR Signaling Pathway antibodies  TCR Signaling Pathway Diagram

Diseases associated with IL-9 active protein

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >42 publications with IL-9 and Immune System Diseases
 Lung Diseases Antibodies  >23 publications with IL-9 and Lung Diseases
 Inflammation Antibodies  >19 publications with IL-9 and Inflammation
 Necrosis Antibodies  >13 publications with IL-9 and Necrosis
 Neoplasms Antibodies  >13 publications with IL-9 and Neoplasms
 Nervous System Diseases Antibodies  >6 publications with IL-9 and Nervous System Diseases
 Eye Diseases Antibodies  >4 publications with IL-9 and Eye Diseases
 Death Antibodies  >3 publications with IL-9 and Death
 Hyperplasia Antibodies  >3 publications with IL-9 and Hyperplasia
 Liver Diseases Antibodies  >2 publications with IL-9 and Liver Diseases

Organs/Tissues associated with IL-9 active protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with IL-9 and Kidney
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