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OAT Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201206

OAT is a 49-kDa nucleus-encoded protein imported into mitochondria to give the mature 48-kDa OAT polypeptide. It has been described in humans, animals, insects, plants and microorganisms. Especially OAT have sex-differential expression in the mouse kidney.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
OAT, Monoclonal Antibody
Full Product Name
OAT
Product Gene Name
anti-OAT antibody
Product Synonym Names
ornithine aminotransferase precursor; DKFZp781A11155; HOGA; OATASE; ornithine aminotransferase precursor EC 2.6.1.13; ornithine aminotransferase (gyrate atrophy); ornithine aminotransferase precursor; Ornithine aminotransferase; mitochondrial precursor; Ornithine oxo-acid aminotransferase; Ornithine--oxo-acid aminotransferase
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
AT23A2
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol
Purity/Purification
By protein-A affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.
OMIM
258870
3D Structure
ModBase 3D Structure for P04181
Antigen Species
Human
Immunogen
Recombinant human OAT (33-439aa) purified from E.coli
Conjugation
Unconjugated
Note
This product was produced from tissue culture supernatant.

Product Categories/Family for anti-OAT antibody

Metabolism; Neuroscience; Signal Transduction; Tags & Cell Markers
Applications Tested/Suitable for anti-OAT antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-OAT antibody
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity.

Immunocytochemistry (ICC)/Immunofluorescence (IF) of anti-OAT antibody

ICC/IF analysis of OAT in HeLa cells. The cell was stained (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
Mouse Anti-OAT Monoclonal Antibody – Cat# MBS201206

Western Blot (WB) of anti-OAT antibody

The lysates(40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human OAT antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Mouse liver tissue lysate Lane 2.: 293T cell lysate
Mouse Anti-OAT Monoclonal Antibody, Western Blot (WB) – Cat# MBS201206

Product References and Citations for anti-OAT antibody

Stranska J, et al. (2008) Plant Signal Behav, 3(11):929-35.; Canas RA, et al. (2008) Plant Physiol, 148(1):77-88.; Levillain O, et al. (2007) Am J Physiol Renal Physiol, 292(3):F1016-27.

Other Notes

Small volumes of anti-OAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OAT purchase

MBS201206 is an antibody targeting OAT. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for OAT. It may not necessarily be applicable to this product.

NCBI GI #
4557809
NCBI GeneID
4942
NCBI Accession #
NP_000265
UniProt Primary Accession #
P04181
UniProt Related Accession #
P04181
GenBank Nucleotide #
NP_000265.1
NCBI Official Full Name
ornithine aminotransferase, mitochondrial isoform 1
NCBI Official Synonym Full Names
ornithine aminotransferase
NCBI Official Symbol
OAT
NCBI Official Synonym Symbols
OKT; GACR; HOGA; OATASE
UniProt Protein Name
Ornithine aminotransferase, mitochondrial
UniProt Synonym Protein Names
Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase
Protein Family
Ornithine aminotransferase
UniProt Gene Name
OAT
UniProt Entry Name
OAT_HUMAN
NCBI Protein Information
ornithine aminotransferase, mitochondrial

NCBI Summary for OAT

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]
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UniProt Comments for OAT

OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Amino Acid Metabolism - arginine and proline; EC 2.6.1.13; Mitochondrial

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding

Biological Process: visual perception; amino acid biosynthetic process

Disease: Gyrate Atrophy Of Choroid And Retina
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Research Articles on OAT

1. Recruitment of a third-degree first cousin consanguineous marriage family with gyrate atrophy of the choroid and retina (GACR) allowed us to identify a novel pathogenic OAT variant in the Chinese population, broadening the mutation spectrum.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-OAT antibody

 Products by Pathway  Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Urea Cycle And Metabolism Of Amino Groups Pathway antibodies  Urea Cycle And Metabolism Of Amino Groups Pathway Diagram
 Arginine Biosynthesis IV Pathway antibodies  Arginine Biosynthesis IV Pathway Diagram
 Arginine Biosynthesis IV Pathway antibodies  Arginine Biosynthesis IV Pathway Diagram
 Arginine Degradation I (arginase Pathway) antibodies  Arginine Degradation I (arginase Pathway) Diagram
 Arginine Degradation I (arginase Pathway) antibodies  Arginine Degradation I (arginase Pathway) Diagram

Diseases associated with anti-OAT antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1249 publications with OAT and Neoplasms
 Carcinoma Antibodies  >1133 publications with OAT and Carcinoma
 Lung Neoplasms Antibodies  >877 publications with OAT and Lung Neoplasms
 Adenocarcinoma Antibodies  >349 publications with OAT and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >285 publications with OAT and Carcinoma, Squamous Cell
 Cardiovascular Diseases Antibodies  >250 publications with OAT and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >206 publications with OAT and Neoplasm Metastasis
 Drug Toxicity Antibodies  >157 publications with OAT and Drug Toxicity
 Heart Diseases Antibodies  >110 publications with OAT and Heart Diseases
 Hyperlipidemias Antibodies  >96 publications with OAT and Hyperlipidemias

Organs/Tissues associated with anti-OAT antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >852 publications with OAT and Lung
 Blood Antibodies  >810 publications with OAT and Blood
 Liver Antibodies  >340 publications with OAT and Liver
 Intestine Antibodies  >272 publications with OAT and Intestine
 Kidney Antibodies  >267 publications with OAT and Kidney
 Brain Antibodies  >222 publications with OAT and Brain
 Heart Antibodies  >127 publications with OAT and Heart
 Bone Antibodies  >121 publications with OAT and Bone
 Vascular Antibodies  >112 publications with OAT and Vascular
 Skin Antibodies  >97 publications with OAT and Skin
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