LSm2 Antibody – Mouse Monoclonal

LSM2 is a member of the LSm family of RNA-binding proteins. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic complex which is thought to be involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2 complex, which is involved in splicing of nuclear mRNAs. LSM2 associates with multiple snRNP complexes containing the U6 snRNA It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.

Luhtala N, Parker R.Nucleic Acids Res. 2009 Sep 37(16):5529-36.; Fernandez CF, Pannone BK, Chen X, Fuchs G, Wolin SL. Mol Biol Cell. 2004Jun 15(6):2842-52.; Achsel T., et al. (1999) EMBO J. 18:5789-5802.

Small volumes of anti-LSm2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS201223 is an antibody targeting LSm2. Reactive in Human. Host: Mouse.