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RANK/TNFRSF11A Recombinant Protein

Name: RANK/TNFRSF11A Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS201240
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201240

RANK, as known as Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A) is a member of the tumor necrosis factor receptor (TNFR) molecular sub-family. It is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

RANK/TNFRSF11A, Recombinant Protein

Full Product Name

Recombinant mouse RANK/TNFRSF11A protein

Product Gene Name

RANK/TNFRSF11A recombinant protein

Product Synonym Names

Tumor necrosis factor receptor superfamily member 11A; Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; activator of NFKB; FEO; OFE; OSTS; PDB2; RANK; RANKLOH18CR1; CD265; CD265 antigen; OPTB7; TRANCER; LOH18CR1; receptor activator of nuclear factor-kappa B

Sequence

VTPPCTQ ERHYEHLGRC CSRCEPGKYL SSKCTPTSDS VCLPCGPDEY LDTWNEEDKC LLHKVCDAGK ALVAVDPGNH TAPRRCACTA GYHWNSDCEC CRRNTECAPG FGAQHPLQLN KDTVCTPCLL GFFSDVFSST DKCKPWTNCT LLGKLEAHQG TTESDVVCSS SMTLRRPPKE AQAYLPS

Host

Baculovirus

Form/Format

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1mg/ml (determined by absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Molecular Weight

47.5 kDa (426aa)

Sequence Positions

31-214aa

3D Structure

ModBase 3D Structure for O35305

Antigen Species

Mouse

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Predicted Nterm

Ala48

Tag Information

hIgG-His-Tag

Product Categories/Family for RANK/TNFRSF11A recombinant protein

Immunology

Applications Tested/Suitable for RANK/TNFRSF11A recombinant protein

SDS-PAGE

Product References and Citations for RANK/TNFRSF11A recombinant protein

Anderson, D.M. et al. (1997) Nature 390, 175-179.;; Nakagawa, N. et al. (1998) Biochem. Biophys. Res. Commun. 245:395-400.;; Bharat B. Aggarwal. (2003) Nature 3, 745-756.;;

Other Notes

Small volumes of RANK/TNFRSF11A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RANK/TNFRSF11A purchase

MBS201240 is a recombinant protein targeting RANK/TNFRSF11A. Also known as Recombinant mouse RANK/TNFRSF11A protein. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for RANK/TNFRSF11A. It may not necessarily be applicable to this product.

NCBI GI #

110350009

NCBI GeneID

21934

NCBI Accession #

NP_033425

UniProt Primary Accession #

O35305

UniProt Related Accession #

O35305

GenBank Nucleotide #

NP_033425.3

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 11A

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 11a, NFKB activator

NCBI Official Symbol

Tnfrsf11a

NCBI Official Synonym Symbols

OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 11A

UniProt Synonym Protein Names

Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265

UniProt Gene Name

Tnfrsf11a

UniProt Synonym Gene Names

Rank; ODFR

UniProt Entry Name

TNR11_MOUSE

NCBI Protein Information

tumor necrosis factor receptor superfamily member 11A

UniProt Comments for RANK/TNFRSF11A

TNFRSF11A: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Protein type: Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; tumor necrosis factor receptor activity; transmembrane receptor activity; cytokine binding; metal ion binding

Biological Process: positive regulation of JNK activity; circadian thermoregulation; adaptive immune response; ossification; tumor necrosis factor-mediated signaling pathway; multicellular organismal development; response to cytokine stimulus; programmed cell death; response to lipopolysaccharide; positive regulation of transcription factor activity; osteoclast differentiation; lymph node development; activation of NF-kappaB transcription factor

Research Articles on RANK/TNFRSF11A

1. We hypothesize that RANKL can stimulate RANK on macrophages and initiate the process of ECM degradation. This process may be inhibited by highly expressed OPG in fibrotic conditions. In this case, RANKL mutants that can bind to RANK without binding to OPG might become promising therapeutic candidates

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RANK/TNFRSF11A recombinant protein

Reference Product	PubMed Publications
Tnfsf11 recombinant protein	>1513 publications with RANK/TNFRSF11A and Tnfsf11
Traf6 recombinant protein	>65 publications with RANK/TNFRSF11A and Traf6
Fos recombinant protein	>49 publications with RANK/TNFRSF11A and Fos
Src recombinant protein	>38 publications with RANK/TNFRSF11A and Src
Traf2 recombinant protein	>15 publications with RANK/TNFRSF11A and Traf2
Traf1 recombinant protein	>8 publications with RANK/TNFRSF11A and Traf1
Traf5 recombinant protein	>8 publications with RANK/TNFRSF11A and Traf5
Traf3 recombinant protein	>6 publications with RANK/TNFRSF11A and Traf3

Pathways associated with RANK/TNFRSF11A recombinant protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Osteoclast Pathway antibodies	Osteoclast Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Prolactin Signaling Pathway antibodies	Prolactin Signaling Pathway Diagram

Diseases associated with RANK/TNFRSF11A recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>893 publications with RANK/TNFRSF11A and Necrosis
Inflammation Antibodies	>155 publications with RANK/TNFRSF11A and Inflammation
Cardiovascular Diseases Antibodies	>112 publications with RANK/TNFRSF11A and Cardiovascular Diseases
Breast Neoplasms Antibodies	>66 publications with RANK/TNFRSF11A and Breast Neoplasms
Osteitis Deformans Antibodies	>53 publications with RANK/TNFRSF11A and Osteitis Deformans
Neoplasm Metastasis Antibodies	>44 publications with RANK/TNFRSF11A and Neoplasm Metastasis
Osteosarcoma Antibodies	>33 publications with RANK/TNFRSF11A and Osteosarcoma
Kidney Diseases Antibodies	>24 publications with RANK/TNFRSF11A and Kidney Diseases
Neoplasms, Experimental Antibodies	>23 publications with RANK/TNFRSF11A and Neoplasms, Experimental
Atherosclerosis Antibodies	>19 publications with RANK/TNFRSF11A and Atherosclerosis

Organs/Tissues associated with RANK/TNFRSF11A recombinant protein

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>78 publications with RANK/TNFRSF11A and Spleen
Prostate Antibodies	>37 publications with RANK/TNFRSF11A and Prostate
Mammary Gland Antibodies	>29 publications with RANK/TNFRSF11A and Mammary Gland
Liver Antibodies	>22 publications with RANK/TNFRSF11A and Liver
Brain Antibodies	>21 publications with RANK/TNFRSF11A and Brain
Kidney Antibodies	>20 publications with RANK/TNFRSF11A and Kidney
Thymus Antibodies	>17 publications with RANK/TNFRSF11A and Thymus
Intestine Antibodies	>9 publications with RANK/TNFRSF11A and Intestine