HYAL1 Recombinant Protein – Cat# MBS201242

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Hyaluronidase 1/HYAL1 (HYAL1) Recombinant Protein

Name: HYAL1 Recombinant Protein; Hyaluronidase 1/HYAL1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS201242
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201242

HYAL1, also known as Hyaluronidase-1, is a member of the endolytic glycoside hydrolase family. Human hyaluronidases (HYALs) are a group of five endo?Nacetylhexosaminidases that include HYAL1, HYAL2, HYAL3, HYAL4, and SPAM1 (PH20). HYAL1 preferentially… More details

$265 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hyaluronidase 1/HYAL1, Recombinant Protein

Full Product Name

Recombinant human Hyaluronidase 1/HYAL1 protein

Product Gene Name

HYAL1 recombinant protein

Product Synonym Names

Hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1; HYAL1; Hyaluronidase 1; Hyaluronoglucosaminidase 1; Hyaluronoglucosaminidase1; LUCA 1; MPS9; NAT6; Plasma hyaluronidase; Tumor suppressor LUCA 1

Sequence

FRGPLLPNRP FTTVWNANTQ WCLERHGVDV DVSVFDVVAN PGQTFRGPDM TIFYSSQLGT YPYYTPTGEP VFGGLPQNAS LIAHLARTFQ DILAAIPAPD FSGLAVIDWE AWRPRWAFNW DTKDIYRQRS RALVQAQHPD WPAPQVEAVA QDQFQGAARA WMAGTLQLGR ALRPRGLWGF YGFPDCYNYD FLSPNYTGQC PSGIRAQNDQ LGWLWGQSRA LYPSIYMPAV LEGTGKSQMY VQHRVAEAFR VAVAAGDPNL PVLPYVQIFY DTTNHFLPLD ELEHSLGESA AQGAAGVVLW VSWENTRTKE SCQAIKEYMD TTLGPFILNV TSGALLCSQA LCSGHGRCVR RTSHPKALLL LNPASFSIQL TPGGGPLSLR GALSLEDQAQ MAVEFKCRCY PGWQAPWCER KSMW

Host

HEK293

Form/Format

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS - PAGE

Concentration

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Molecular Weight

46.9kDa (420aa)

Sequence Positions

22-435aa

OMIM

607071

3D Structure

ModBase 3D Structure for Q12794

Antigen Species

Human

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Predicted Nterm

Phe12

Tag Information

His-Tag

Product Categories/Family for HYAL1 recombinant protein

Signal Transduction, Cytoskeleton

Applications Tested/Suitable for HYAL1 recombinant protein

SDS-PAGE

Product References and Citations for HYAL1 recombinant protein

Csoka, A.B. et al. (2001) Matrix Biol. 20:499-508.;; Jedrzejas, M. J. and Stern, R. (2005) Proteins 61:227-238.;; Frost, GI. et al. (1997) Biochem. Biophys. Res. Commun. 236:10-15.;;

Other Notes

Small volumes of HYAL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HYAL1 purchase

MBS201242 is a recombinant protein targeting HYAL1. Also known as Recombinant human Hyaluronidase 1/HYAL1 protein. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for HYAL1. It may not necessarily be applicable to this product.

NCBI GI #

24497562

NCBI GeneID

3373

NCBI Accession #

NP_149349

UniProt Primary Accession #

Q12794

UniProt Related Accession #

Q12794

GenBank Nucleotide #

NP_149349.2

NCBI Official Full Name

hyaluronidase-1 isoform 1

NCBI Official Synonym Full Names

hyaluronidase 1

NCBI Official Symbol

HYAL1

NCBI Official Synonym Symbols

MPS9; NAT6; LUCA1; HYAL-1

UniProt Protein Name

Hyaluronidase-1

UniProt Synonym Protein Names

Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1

UniProt Gene Name

HYAL1

UniProt Synonym Gene Names

LUCA1; Hyal-1; LuCa-1

UniProt Entry Name

HYAL1_HUMAN

NCBI Protein Information

hyaluronidase-1

NCBI Summary for HYAL1

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for HYAL1

HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.1.35; Glycan Metabolism - glycosaminoglycan degradation; Secreted, signal peptide; Secreted; Hydrolase

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: extracellular space; lysosomal lumen; lysosome; cytoplasm; cytoplasmic vesicle

Molecular Function: viral receptor activity; hyaluronan synthase activity; transcription factor binding; hyalurononglucosaminidase activity

Biological Process: positive regulation of cell adhesion; glycosaminoglycan metabolic process; response to virus; pathogenesis; positive regulation of cell growth; hyaluronan catabolic process; response to antibiotic; chondroitin sulfate metabolic process; positive regulation of angiogenesis; response to reactive oxygen species; hyaluronan biosynthetic process; cartilage development; carbohydrate metabolic process; chondroitin sulfate catabolic process; negative regulation of cell growth; inflammatory response; hyaluronan metabolic process; positive regulation of growth; positive regulation of epithelial cell proliferation

Disease: Mucopolysaccharidosis, Type Ix

Research Articles on HYAL1

1. HYAL1/2 suppress colorectal cancer cell metastasis by regulating MMPs/TIMPs balance and rearranging F-actin distribution, inhibiting invasion and migration of cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HYAL1 recombinant protein

Products by Pathway	Pathway Diagram
CS/DS Degradation Pathway antibodies	CS/DS Degradation Pathway Diagram
Chondroitin Sulfate Degradation Pathway antibodies	Chondroitin Sulfate Degradation Pathway Diagram
Chondroitin Sulfate Degradation Pathway antibodies	Chondroitin Sulfate Degradation Pathway Diagram
Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies	Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
Dermatan Sulfate Degradation Pathway antibodies	Dermatan Sulfate Degradation Pathway Diagram
Dermatan Sulfate Degradation Pathway antibodies	Dermatan Sulfate Degradation Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram

Diseases associated with HYAL1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>43 publications with HYAL1 and Neoplasms
Neoplasm Metastasis Antibodies	>9 publications with HYAL1 and Neoplasm Metastasis
Adenocarcinoma Antibodies	>9 publications with HYAL1 and Adenocarcinoma
Necrosis Antibodies	>8 publications with HYAL1 and Necrosis
Inflammation Antibodies	>7 publications with HYAL1 and Inflammation
Urinary Bladder Neoplasms Antibodies	>5 publications with HYAL1 and Urinary Bladder Neoplasms
Kidney Diseases Antibodies	>4 publications with HYAL1 and Kidney Diseases
Muscular Diseases Antibodies	>2 publications with HYAL1 and Muscular Diseases
Liver Neoplasms Antibodies	>2 publications with HYAL1 and Liver Neoplasms
Atherosclerosis Antibodies	>2 publications with HYAL1 and Atherosclerosis

Organs/Tissues associated with HYAL1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>19 publications with HYAL1 and Blood
Lung Antibodies	>14 publications with HYAL1 and Lung
Kidney Antibodies	>12 publications with HYAL1 and Kidney
Prostate Antibodies	>10 publications with HYAL1 and Prostate
Vascular Antibodies	>7 publications with HYAL1 and Vascular
Bladder Antibodies	>7 publications with HYAL1 and Bladder
Muscle Antibodies	>5 publications with HYAL1 and Muscle
Liver Antibodies	>5 publications with HYAL1 and Liver
Ovary Antibodies	>4 publications with HYAL1 and Ovary
Brain Antibodies	>3 publications with HYAL1 and Brain