Interleukin 27 Receptor Alpha (IL27Ra) Antibody – Rabbit Polyclonal

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]

IL27RA: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. Belongs to the type I cytokine receptor family. Type 2 subfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: interleukin-27 receptor activity; transmembrane receptor activity

Biological Process: cell surface receptor signaling pathway; defense response to Gram-positive bacterium; immune response; negative regulation of T-helper 2 type immune response; positive regulation of interferon-gamma production; positive regulation of T-helper 1 type immune response; regulation of isotype switching to IgG isotypes