Endothelin 1 (EDN1) Antibody – Rabbit Polyclonal

This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis. [provided by RefSeq, Feb 2016]

EDN1: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13 A4|13 20.82 cM

Cellular Component: cytoplasm; extracellular region; extracellular space

Molecular Function: cytokine activity; endothelin A receptor binding; endothelin B receptor binding; hormone activity; protein binding; receptor binding

Biological Process: artery smooth muscle contraction; blood vessel morphogenesis; body fluid secretion; branching involved in blood vessel morphogenesis; calcium-mediated signaling; cartilage development; cell growth; cell surface receptor signaling pathway; cell-cell signaling; dorsal/ventral pattern formation; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); epithelial fluid transport; G-protein coupled receptor signaling pathway; G-protein signaling, phospholipase D activating pathway; glucose transport; heart development; histamine secretion; in utero embryonic development; inositol phosphate-mediated signaling; membrane depolarization; middle ear morphogenesis; negative regulation of cAMP biosynthetic process; negative regulation of cellular protein metabolic process; negative regulation of hormone secretion; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; nitric oxide transport; peptide hormone secretion; phosphoinositide 3-kinase cascade; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell size; positive regulation of heart rate; positive regulation of hormone secretion; positive regulation of JUN kinase activity; positive regulation of MAP kinase activity; positive regulation of mitotic nuclear division; positive regulation of odontogenesis; positive regulation of prostaglandin secretion; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; prostaglandin biosynthetic process; protein kinase C deactivation; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of blood pressure; regulation of blood vessel size; regulation of pH; regulation of sensory perception of pain; regulation of systemic arterial blood pressure by endothelin; regulation of vasoconstriction; respiratory gaseous exchange; response to hypoxia; rhythmic excitation; sensory perception of pain; skeletal system development; superoxide anion generation; vasoconstriction; vein smooth muscle contraction