Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) Antibody – Rabbit Polyclonal

SLAM: a type I membrane protein present on the surface of B cells, T cells and CD83+ dendritic cells. A high-affinity self-ligand considered to be important in bidirectional T <-> B-cell stimulation. SLAM-induced signal-transduction events in T lymphocytes are different from those in B cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A (SAP) acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (SHP-2)-dependent signal transduction operates. Its cytoplasmic domain interacts with SAP through part of its SH2 domain, and with SHP-2. Three alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cell surface; extracellular exosome; integral component of membrane; plasma membrane

Molecular Function: antigen binding; identical protein binding; protein binding; transmembrane receptor activity; viral receptor activity

Biological Process: adaptive immune response; cell adhesion; entry of virus into host cell; innate immune response; lymphocyte activation; myeloid dendritic cell activation involved in immune response; negative regulation of CD40 signaling pathway; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; phagocytosis; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade; signal transduction