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UDP Glycosyltransferase 8 (UGT8) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2013902
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MBS2013902 is an antibody targeting UGT8. Also known as Polyclonal Antibody to UDP Glycosyltransferase 8 (UGT8). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UDP Glycosyltransferase 8 (UGT8), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to UDP Glycosyltransferase 8 (UGT8)
Product Gene Name
anti-UGT8 antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S- GVY LISRLGVSFL VLPKYERIMQ KYNLLPEKSM YDLVHGSSLW MLCTDVALEF PRPTLPNVVY VGGILTKPAS PLPEDLQRWV NGANEHGFVL VSFGAGVKYL SEDIANKLAG ALGRLPQKVI WRFSGPKPKN LGNNTKLIEW LPQNDLLGHS KIKAFLSHGG LNSIFETIYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE WKTVTEKELY EALVKVINNP SYRQRAQKLS EIHKDQPGHP VNRTIYWIDY IIRHNGAHHL RAAVHQISFC QYFLLDIAFV LLLGAALLYF LLSWVTKFIY RKIKSLWSRN KHSTVNGHYH NGILNGKYKR NGHIKHEKKV K
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against UGT8. It has been selected for its ability to recognize UGT8 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: UGT8 (MBS2013902)
Immunogen: UGT8 (MBS2018221)
Matching Pairs
Unconjugated Antibody: UGT8 (MBS2013902)
APC-CY7 Conjugated Antibody: UGT8 (MBS2078829)
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Molecular Weight
61,438 Da
OMIM
U30930 mRNA
3D Structure
ModBase 3D Structure for Q16880
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant UGT8 (Gly198~Lys541) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2078831
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-UGT8 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-UGT8 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-UGT8 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-UGT8 Polyclonal Antibody – Cat# MBS2013902

Immunohistochemistry (IHC) of anti-UGT8 antibody

DABstainingonIHC-P.Samples:HumanTissue)
Rabbit Anti-UGT8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2013902

Other Notes

Small volumes of anti-UGT8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UGT8. It may not necessarily be applicable to this product.

NCBI GI #
189491660
NCBI GeneID
7368
NCBI Accession #
NP_001121646.1
UniProt Primary Accession #
Q16880
UniProt Secondary Accession #
O00196; B3KXU7
UniProt Related Accession #
Q16880
GenBank Nucleotide #
NM_001128174.2
NCBI Official Full Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
NCBI Official Synonym Full Names
UDP glycosyltransferase 8
NCBI Official Symbol
UGT8
NCBI Official Synonym Symbols
CGT; UGT4
UniProt Protein Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
UniProt Synonym Protein Names
Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase
Protein Family
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
UniProt Gene Name
UGT8
UniProt Synonym Gene Names
CGT; UGT4
NCBI Protein Information
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

NCBI Summary for UGT8

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
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UniProt Comments for UGT8

UGT8: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Belongs to the UDP-glycosyltransferase family.

Protein type: EC 2.4.1.45; Lipid Metabolism - sphingolipid; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: integral component of membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function: glucuronosyltransferase activity; N-acylsphingosine galactosyltransferase activity; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

Biological Process: central nervous system development; cytoskeleton organization; galactosylceramide biosynthetic process; glycosphingolipid metabolic process; neuron projection morphogenesis; paranodal junction assembly; peripheral nervous system development
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Research Articles on UGT8

1. An increase in the immunolabelling of ceramide was observed in cells where UDP glycosyltransferase 8 (UGT8) was down-regulated as opposed to cells where UGT8 was either not regulated or was up-regulated.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UGT8 antibody

 Reference Product  PubMed Publications
 ARSA antibody  >2 publications with UGT8 and ARSA
 ASAH1 antibody  >2 publications with UGT8 and ASAH1
 UGCG antibody  >2 publications with UGT8 and UGCG
 GAL3ST1 antibody  >2 publications with UGT8 and GAL3ST1
 SMPD2 antibody  >1 publications with UGT8 and SMPD2
 GBA antibody  >1 publications with UGT8 and GBA
 CERK antibody  >1 publications with UGT8 and CERK
 SGPP1 antibody  >1 publications with UGT8 and SGPP1

Pathways associated with anti-UGT8 antibody

 Products by Pathway  Pathway Diagram
 Cerebroside And Sulfatide Biosynthesis Pathway antibodies  Cerebroside And Sulfatide Biosynthesis Pathway Diagram
 Cerebroside And Sulfatide Biosynthesis Pathway antibodies  Cerebroside And Sulfatide Biosynthesis Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram

Diseases associated with anti-UGT8 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with UGT8 and Brain Diseases
 Abnormalities, Multiple Antibodies  >2 publications with UGT8 and Abnormalities, Multiple
 Kidney Diseases Antibodies  >2 publications with UGT8 and Kidney Diseases
 Confusion Antibodies  >1 publications with UGT8 and Confusion
 Liver Diseases Antibodies  >1 publications with UGT8 and Liver Diseases
 Fatty Liver Antibodies  >1 publications with UGT8 and Fatty Liver
 Congenital Abnormalities Antibodies  >1 publications with UGT8 and Congenital Abnormalities
 Inflammation Antibodies  >1 publications with UGT8 and Inflammation

Organs/Tissues associated with anti-UGT8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with UGT8 and Brain
 Kidney Antibodies  >4 publications with UGT8 and Kidney
 Lung Antibodies  >3 publications with UGT8 and Lung
 Liver Antibodies  >2 publications with UGT8 and Liver
 Intestine Antibodies  >1 publications with UGT8 and Intestine
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