Macrophage Stimulating 1 Receptor (MST1R) Antibody – Rabbit Polyclonal

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

Ron: a receptor tyrosine kinase of the Met family. Receptor for macrophage stimulating protein. Can be desensitized by c-Cbl and its binding partner Grb2. Overexpression of wild-type RON causes the formation of lung tumors. Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Met family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell surface; integral component of plasma membrane; plasma membrane; stress fiber; vacuole

Molecular Function: ATP binding; enzyme binding; macrophage colony-stimulating factor receptor activity; protein binding

Biological Process: cell motility; defense response; hepatocyte growth factor receptor signaling pathway; innate immune response; macrophage colony-stimulating factor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; response to virus; signal transduction; single fertilization

Disease: Nasopharyngeal Carcinoma, Susceptibility To, 3