Protocadherin 1 (PCDH1) Antibody – Rabbit Polyclonal

This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008]

PCDH1: a protocadherin protein within the cadherin superfamily. A membrane protein found at cell-cell boundaries. Involved in neural cell adhesion, suggesting a possible role in neuronal development. Contains an extracelllular region with 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: cell junction; integral component of plasma membrane; intercellular junction; intracellular membrane-bound organelle; nucleolus; nucleus; plasma membrane

Molecular Function: calcium ion binding

Biological Process: cell-cell signaling; homophilic cell adhesion; nervous system development