Dishevelled, Dsh Homolog 2 (DVL2) Antibody – Rabbit Polyclonal

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: aggresome; apical part of cell; clathrin-coated endocytic vesicle; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; nuclear body; nucleoplasm; nucleus

Molecular Function: frizzled binding; identical protein binding; protein binding; protein binding, bridging; protein domain specific binding; protein kinase binding; protein self-association; Rac GTPase binding

Biological Process: beta-catenin destruction complex disassembly; canonical Wnt signaling pathway involved in regulation of cell proliferation; cellular protein localization; cochlea morphogenesis; convergent extension involved in neural plate elongation; heart development; negative regulation of canonical Wnt signaling pathway; neural tube closure; outflow tract morphogenesis; planar cell polarity pathway involved in neural tube closure; positive regulation of canonical Wnt signaling pathway; positive regulation of GTPase activity; positive regulation of JUN kinase activity; positive regulation of protein phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-templated; protein oligomerization; segment specification; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway; Wnt signaling pathway